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Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 140919, updated on 31-Jan-2023

Summary

Official Symbol
Slc17a6provided by MGI
Official Full Name
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6provided by MGI
Primary source
MGI:MGI:2156052
See related
Ensembl:ENSMUSG00000030500 AllianceGenome:MGI:2156052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNPI; VGLUT2; 2900073D12Rik
Summary
Enables L-glutamate transmembrane transporter activity. Involved in hyaloid vascular plexus regression. Acts upstream of or within neurotransmitter uptake. Located in synaptic vesicle. Is expressed in several structures, including cranial ganglion; nervous system; sensory organ; tail mesenchyme; and testis. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 12.2), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
Orthologs
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Genomic context

See Slc17a6 in Genome Data Viewer
Location:
7; 7 B4
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51271578..51320874)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51621830..51671126)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9354 Neighboring gene predicted gene, 33190 Neighboring gene anoctamin 5 Neighboring gene predicted gene, 33136 Neighboring gene predicted gene, 42402 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (16)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate uniporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamate uniporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurotransmitter uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse structure or activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium-dependent phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in pericellular basket ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vesicular glutamate transporter 2
Names
differentiation-associated BNPI
differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
solute carrier family 17 (vesicular glutamate transporter), member 6
solute carrier family 17 member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355150.1NP_001342079.1  vesicular glutamate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113306, AC163335
    Conserved Domains (1) summary
    cl27298
    Location:1436
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  2. NM_080853.3NP_543129.3  vesicular glutamate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_543129.3

    Status: VALIDATED

    Source sequence(s)
    AF324864, BB304814, BC038375, CB519039, CD578992
    Consensus CDS
    CCDS39969.1
    UniProtKB/Swiss-Prot
    Q8BLE7
    UniProtKB/TrEMBL
    A0A0R4J0A6
    Related
    ENSMUSP00000032710.6, ENSMUST00000032710.7
    Conserved Domains (2) summary
    cd06174
    Location:75498
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:70511
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    51271578..51320874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540601.5XP_006540664.1  vesicular glutamate transporter 2 isoform X1

    Conserved Domains (1) summary
    cd17382
    Location:47471
    MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters