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Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 [ Mus musculus (house mouse) ]

Gene ID: 140918, updated on 8-Dec-2022

Summary

Official Symbol
Slc7a12provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12provided by MGI
Primary source
MGI:MGI:2156159
See related
Ensembl:ENSMUSG00000039710 AllianceGenome:MGI:2156159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XAT1; Asc-2
Summary
Enables amino acid transmembrane transporter activity. Acts upstream of or within amino acid transport. Located in cytoplasm and plasma membrane. Orthologous to human SLC7A13 (solute carrier family 7 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 34.7) See more
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Genomic context

See Slc7a12 in Genome Data Viewer
Location:
3; 3 A1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14545757..14570879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14480697..14505819)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene leucine rich repeat and coiled-coil domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within amino acid transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Names
Asc-2,asc-type amino acid transporter 2
asc-type amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080852.3NP_543128.1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12

    See identical proteins and their annotated locations for NP_543128.1

    Status: VALIDATED

    Source sequence(s)
    AC131593, AC163676
    Consensus CDS
    CCDS17246.1
    UniProtKB/TrEMBL
    Q8VIE6
    Related
    ENSMUSP00000038574.8, ENSMUST00000037321.8
    Conserved Domains (1) summary
    pfam13520
    Location:7412
    AA_permease_2; Amino acid permease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    14545757..14570879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530052.2XP_006530115.1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:2377
    2A0308; L-type amino acid transporter