Format

Send to:

Choose Destination

CNBD2 cyclic nucleotide binding domain containing 2 [ Homo sapiens (human) ]

Gene ID: 140894, updated on 21-Dec-2019

Summary

Official Symbol
CNBD2provided by HGNC
Official Full Name
cyclic nucleotide binding domain containing 2provided by HGNC
Primary source
HGNC:HGNC:16145
See related
Ensembl:ENSG00000149646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNMPD1; C20orf152
Expression
Biased expression in testis (RPKM 3.5) and kidney (RPKM 0.1) See more
Orthologs

Genomic context

See CNBD2 in Genome Data Viewer
Location:
20q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35954561..36030700)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34556529..34618622)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene SCAN domain containing 1 Neighboring gene non-coding RNA activated by DNA damage Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene high mobility group box 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC138880

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclic nucleotide-binding domain-containing protein 2
Names
cyclic nucleotide (cNMP) binding domain containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207076.3NP_001194005.1  cyclic nucleotide-binding domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001194005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, which results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AI191598, BC114945, HY023889
    Consensus CDS
    CCDS56189.1
    UniProtKB/Swiss-Prot
    Q96M20
    Related
    ENSP00000442729.1, ENST00000538900.1
    Conserved Domains (2) summary
    COG0664
    Location:110241
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:122218
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001304367.2NP_001291296.1  cyclic nucleotide-binding domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001291296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL109965, BC030782, HY023889
    Consensus CDS
    CCDS77575.1
    UniProtKB/TrEMBL
    Q4G141
    Related
    ENSP00000480804.1, ENST00000489667.1
  3. NM_001365709.1NP_001352638.1  cyclic nucleotide-binding domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL109965, AL359828
    Related
    ENSP00000363084.3, ENST00000373973.7
    Conserved Domains (1) summary
    cd00038
    Location:122218
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_080834.4NP_543024.2  cyclic nucleotide-binding domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_543024.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI191598, AK057454, BC114945, HY023889
    Consensus CDS
    CCDS13270.1
    UniProtKB/Swiss-Prot
    Q96M20
    Related
    ENSP00000340954.1, ENST00000349339.5
    Conserved Domains (2) summary
    COG0664
    Location:110241
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:122218
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RNA

  1. NR_130714.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI191598, BC114634, HY023889
    Related
    ENST00000463258.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35954561..36030700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528593.2XP_011526895.1  cyclic nucleotide-binding domain-containing protein 2 isoform X5

  2. XM_011528590.2XP_011526892.1  cyclic nucleotide-binding domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    COG0664
    Location:151282
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:163259
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. XM_017027683.2XP_016883172.1  cyclic nucleotide-binding domain-containing protein 2 isoform X3

  4. XM_011528592.1XP_011526894.1  cyclic nucleotide-binding domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    COG0664
    Location:63194
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:75171
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  5. XM_011528598.1XP_011526900.1  cyclic nucleotide-binding domain-containing protein 2 isoform X6

RNA

  1. XR_001754188.1 RNA Sequence

  2. XR_001754187.1 RNA Sequence

Support Center