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SIRPA signal regulatory protein alpha [ Homo sapiens (human) ]

Gene ID: 140885, updated on 9-Dec-2018

Summary

Official Symbol
SIRPAprovided by HGNC
Official Full Name
signal regulatory protein alphaprovided by HGNC
Primary source
HGNC:HGNC:9662
See related
Ensembl:ENSG00000198053 MIM:602461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues See more
Orthologs

Genomic context

See SIRPA in Genome Data Viewer
Location:
20p13
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (1894167..1939895)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1874763..1920540)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984104 Neighboring gene uncharacterized LOC105372501 Neighboring gene uncharacterized LOC107984088 Neighboring gene uncharacterized LOC102724545 Neighboring gene PDYN antisense RNA 1 Neighboring gene prodynorphin Neighboring gene ribosomal protein L7 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog
Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

Pathways from BioSystems

  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion mediator activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interferon-gamma ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-12 IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
monocyte extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of I-kappaB phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of chemokine (C-C motif) ligand 5 production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage inflammatory protein 1 alpha production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type substrate 1
Names
CD172 antigen-like family member A
brain-immunoglobulin-like molecule with tyrosine-based activation motifs
inhibitory receptor SHPS-1
macrophage fusion receptor
myd-1 antigen
tyrosine phosphatase SHP substrate 1
NP_001035111.1
NP_001035112.1
NP_001317657.1
NP_542970.1
XP_005260727.1
XP_006723608.1
XP_011527475.1
XP_024307604.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040022.1NP_001035111.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001035111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL034562, BC075849, DA471662, DN989886
    Consensus CDS
    CCDS13022.1
    UniProtKB/Swiss-Prot
    P78324
    Related
    ENSP00000382941.4, ENST00000400068.7
    Conserved Domains (4) summary
    cd00098
    Location:266339
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41144
    IG_like; Immunoglobulin like
    pfam07686
    Location:38145
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:143254
    Ig; Immunoglobulin domain
  2. NM_001040023.1NP_001035112.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001035112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL034562, BC038510, DN989886
    Consensus CDS
    CCDS13022.1
    UniProtKB/Swiss-Prot
    P78324
    Related
    ENSP00000351621.4, ENST00000358771.4
    Conserved Domains (4) summary
    cd00098
    Location:266339
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41144
    IG_like; Immunoglobulin like
    pfam07686
    Location:38145
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:143254
    Ig; Immunoglobulin domain
  3. NM_001330728.1NP_001317657.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longer protein (isoform 2).
    Source sequence(s)
    AL034562, BC026692, BC033092, DA471662, DN989886
    Consensus CDS
    CCDS82593.1
    UniProtKB/Swiss-Prot
    P78324
    Related
    ENSP00000478763.1, ENST00000622179.4
    Conserved Domains (3) summary
    cd05772
    Location:147250
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:252355
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cd16097
    Location:35145
    IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)
  4. NM_080792.2NP_542970.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_542970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AB023430, AL034562
    Consensus CDS
    CCDS13022.1
    UniProtKB/Swiss-Prot
    P78324
    Related
    ENSP00000348307.3, ENST00000356025.7
    Conserved Domains (4) summary
    cd00098
    Location:266339
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41144
    IG_like; Immunoglobulin like
    pfam07686
    Location:38145
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:143254
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    1894167..1939895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260670.3XP_005260727.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_005260727.1

    UniProtKB/Swiss-Prot
    P78324
    Conserved Domains (3) summary
    cd05772
    Location:147250
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:252355
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cd16097
    Location:35145
    IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)
  2. XM_024451836.1XP_024307604.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    Conserved Domains (3) summary
    cd05772
    Location:147250
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:252355
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cd16097
    Location:35145
    IgV_SIRP; Immunoglobulin (Ig)-like domain of Signal-Regulatory Protein (SIRP)
  3. XM_006723545.4XP_006723608.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:41144
    IG_like; Immunoglobulin like
    pfam07686
    Location:38145
    V-set; Immunoglobulin V-set domain
  4. XM_011529173.2XP_011527475.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    Conserved Domains (4) summary
    cd00098
    Location:266339
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41122
    IG_like; Immunoglobulin like
    pfam07686
    Location:38145
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:143254
    Ig; Immunoglobulin domain
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