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ZNF280B zinc finger protein 280B [ Homo sapiens (human) ]

Gene ID: 140883, updated on 23-Nov-2021

Summary

Official Symbol
ZNF280Bprovided by HGNC
Official Full Name
zinc finger protein 280Bprovided by HGNC
Primary source
HGNC:HGNC:23022
See related
Ensembl:ENSG00000275004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUHW2; ZNF279; ZNF632; 5'OY11.1; D87009.C22.3
Summary
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]
Expression
Biased expression in testis (RPKM 11.7), brain (RPKM 1.5) and 4 other tissues See more
Orthologs
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Genomic context

See ZNF280B in Genome Data Viewer
Location:
22q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (22484421..22509161, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22838767..22863060, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit pseudogene Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene zinc finger protein 280A Neighboring gene PRAME nuclear receptor transcriptional regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 280B
Names
suppressor of hairy wing homolog 2
zinc finger protein 279
zinc finger protein 632

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    462755..487493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080764.4NP_542942.2  zinc finger protein 280B

    See identical proteins and their annotated locations for NP_542942.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AC245291, AK097608, AW021601
    Consensus CDS
    CCDS13799.1
    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8, B3KUN2
    Related
    ENSP00000485750.1, ENST00000626650.3
    Conserved Domains (2) summary
    sd00017
    Location:345366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45225
    DUF4195; Domain of unknown function (DUF4195)

RNA

  1. NR_130642.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC245291, AK097608, AW021601, BC040020
  2. NR_130643.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' end and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC245291, AW021601, BI523641

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    22484421..22509161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529897.2XP_011528199.1  zinc finger protein 280B isoform X1

    See identical proteins and their annotated locations for XP_011528199.1

    UniProtKB/Swiss-Prot
    Q86YH2
    UniProtKB/TrEMBL
    A0A0D9SEJ8
    Conserved Domains (2) summary
    sd00017
    Location:345366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45225
    DUF4195; Domain of unknown function (DUF4195)

RNA

  1. XR_002958668.1 RNA Sequence

  2. XR_002958667.1 RNA Sequence

  3. XR_002958666.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187629.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    120078..144399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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