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WFDC6 WAP four-disulfide core domain 6 [ Homo sapiens (human) ]

Gene ID: 140870, updated on 23-Nov-2021

Summary

Official Symbol
WFDC6provided by HGNC
Official Full Name
WAP four-disulfide core domain 6provided by HGNC
Primary source
HGNC:HGNC:16164
See related
Ensembl:ENSG00000243543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP6; C20orf171; HEL-S-295; dJ461P17.11
Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]
Expression
Restricted expression toward testis (RPKM 26.2) See more
Orthologs
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Genomic context

See WFDC6 in Genome Data Viewer
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45534196..45539482, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44162835..44168121, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987282 Neighboring gene ribosomal protein L5 pseudogene 2 Neighboring gene serine peptidase inhibitor, Kunitz type 3 Neighboring gene EPPIN-WFDC6 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 21 Neighboring gene epididymal peptidase inhibitor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough EPPIN-WFDC6

Readthrough gene: EPPIN-WFDC6, Included gene: EPPIN

Homology

Clone Names

  • MGC126649, MGC126653

General protein information

Preferred Names
WAP four-disulfide core domain protein 6
Names
epididymis secretory protein Li 295
epididymis secretory sperm binding protein
protease inhibitor WAP6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080827.2NP_543017.1  WAP four-disulfide core domain protein 6 precursor

    See identical proteins and their annotated locations for NP_543017.1

    Status: REVIEWED

    Source sequence(s)
    AF411861, AL031663
    Consensus CDS
    CCDS13358.1
    UniProtKB/Swiss-Prot
    Q9BQY6
    UniProtKB/TrEMBL
    A0A0K0K1K0
    Related
    ENSP00000361755.3, ENST00000372670.8
    Conserved Domains (1) summary
    pfam00095
    Location:3370
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45534196..45539482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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