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Fscn1 fascin actin-bundling protein 1 [ Mus musculus (house mouse) ]

Gene ID: 14086, updated on 5-Feb-2023

Summary

Official Symbol
Fscn1provided by MGI
Official Full Name
fascin actin-bundling protein 1provided by MGI
Primary source
MGI:MGI:1352745
See related
Ensembl:ENSMUSG00000029581 AllianceGenome:MGI:1352745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fan1; fascin-1
Summary
Enables actin filament binding activity. Involved in cell migration and positive regulation of filopodium assembly. Acts upstream of or within actin filament bundle assembly. Located in filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 192.6), CNS E14 (RPKM 164.7) and 21 other tissues See more
Orthologs
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Genomic context

See Fscn1 in Genome Data Viewer
Location:
5 G2; 5 81.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142946110..142958944)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142960355..142973189)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 18 Neighboring gene predicted gene, 38733 Neighboring gene actin, beta Neighboring gene VISTA enhancer mm1619 Neighboring gene ring finger protein 216 Neighboring gene predicted gene 43380

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of apical/basal cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microspike assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in parallel actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in microspike ISO
Inferred from Sequence Orthology
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fascin
Names
fascin 1
singed-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007984.2NP_032010.2  fascin

    See identical proteins and their annotated locations for NP_032010.2

    Status: VALIDATED

    Source sequence(s)
    BC052408, BY311024, CJ286472
    Consensus CDS
    CCDS19834.1
    UniProtKB/Swiss-Prot
    Q61553, Q80V75
    UniProtKB/TrEMBL
    A0A6P5PKU6, A0A8C6ID00
    Related
    ENSMUSP00000031565.9, ENSMUST00000031565.15
    Conserved Domains (2) summary
    cd00257
    Location:383493
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:268378
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142946110..142958944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)