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DEFB127 defensin beta 127 [ Homo sapiens (human) ]

Gene ID: 140850, updated on 9-Jun-2025
Official Symbol
DEFB127provided by HGNC
Official Full Name
defensin beta 127provided by HGNC
Primary source
HGNC:HGNC:16206
See related
Ensembl:ENSG00000088782 AllianceGenome:HGNC:16206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEF-27; DEFB27; hBD-27; DEFB-27; C20orf73; bA530N10.2
Summary
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Orthologs
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See DEFB127 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (157454..159163)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (199981..201681)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (138095..139804)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:83775-84276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:84277-84776 Neighboring gene NANOG hESC enhancer GRCh37_chr20:126538-127039 Neighboring gene defensin beta 126 Neighboring gene defensin beta 128 Neighboring gene defensin beta 129

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
beta-defensin 127
Names
beta-defensin 27

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139074.4NP_620713.1  beta-defensin 127 preproprotein

    See identical proteins and their annotated locations for NP_620713.1

    Status: REVIEWED

    Source sequence(s)
    AA454191, AL360078, AY122479, AY358796
    Consensus CDS
    CCDS12991.1
    UniProtKB/Swiss-Prot
    Q14DW7, Q9H1M4
    UniProtKB/TrEMBL
    Q14DW6
    Related
    ENSP00000371825.3, ENST00000382388.4
    Conserved Domains (1) summary
    pfam13841
    Location:2354
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    157454..159163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    199981..201681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)