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NEURL2 neuralized E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 140825, updated on 8-Jul-2021

Summary

Official Symbol
NEURL2provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:16156
See related
Ensembl:ENSG00000124257 MIM:608597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OZZ; OZZ-E3; C20orf163
Summary
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in kidney (RPKM 2.2), ovary (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See NEURL2 in Genome Data Viewer
Location:
20q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45888634..45891208, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44517273..44519847, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene spermatogenesis associated 25 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene phosphorylated CTD interacting factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125934, MGC125935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuralized-like protein 2
Names
neuralized homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033108.1 RefSeqGene

    Range
    5001..7816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278535.2NP_001265464.1  neuralized-like protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK054821, AW298115
    UniProtKB/Swiss-Prot
    Q9BR09
    Conserved Domains (1) summary
    cd12887
    Location:25242
    SPRY_NHR_like; SPRY domain in neuralized homology repeat
  2. NM_080749.4NP_542787.1  neuralized-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_542787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK054821, HY058356
    Consensus CDS
    CCDS13384.1
    UniProtKB/Swiss-Prot
    Q9BR09
    Related
    ENSP00000361596.4, ENST00000372518.5
    Conserved Domains (2) summary
    smart00969
    Location:249285
    SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases
    cd12887
    Location:25242
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45888634..45891208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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