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ROMO1 reactive oxygen species modulator 1 [ Homo sapiens (human) ]

Gene ID: 140823, updated on 21-Jan-2020

Summary

Official Symbol
ROMO1provided by HGNC
Official Full Name
reactive oxygen species modulator 1provided by HGNC
Primary source
HGNC:HGNC:16185
See related
Ensembl:ENSG00000125995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTGM; MTGMP; C20orf52; bA353C18.2
Summary
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues See more
Orthologs

Genomic context

See ROMO1 in Genome Data Viewer
Location:
20q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35699310..35700982)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34287232..34288902)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene copine 1 Neighboring gene RNA, U6 small nuclear 759, pseudogene Neighboring gene RNA binding motif protein 12 Neighboring gene NFS1 cysteine desulfurase Neighboring gene RNA binding motif protein 39 Neighboring gene ribosome production factor 2 homolog pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111180

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
reactive oxygen species modulator 1
Names
PCM19
ROS modulator 1
epididymis tissue protein Li 175
glyrichin
mitochondrial targeting GXXXG protein
mitochondrial targeting GxxxG motif protein
protein MGR2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080748.3NP_542786.1  reactive oxygen species modulator 1

    See identical proteins and their annotated locations for NP_542786.1

    Status: REVIEWED

    Source sequence(s)
    AK000548, BC105281
    Consensus CDS
    CCDS13264.1
    UniProtKB/Swiss-Prot
    P60602
    Related
    ENSP00000363190.3, ENST00000374077.8
    Conserved Domains (1) summary
    pfam10247
    Location:1479
    Romo1; Reactive mitochondrial oxygen species modulator 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35699310..35700982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027678.1XP_016883167.1  reactive oxygen species modulator 1 isoform X1

    UniProtKB/Swiss-Prot
    P60602
    Related
    ENSP00000363191.1, ENST00000374078.5
    Conserved Domains (1) summary
    pfam10247
    Location:1479
    Romo1; Reactive mitochondrial oxygen species modulator 1
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