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ROMO1 reactive oxygen species modulator 1 [ Homo sapiens (human) ]

Gene ID: 140823, updated on 8-Apr-2026
Official Symbol
ROMO1provided by HGNC
Official Full Name
reactive oxygen species modulator 1provided by HGNC
Primary source
HGNC:HGNC:16185
See related
Ensembl:ENSG00000125995 MIM:618894; AllianceGenome:HGNC:16185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTGM; MTGMP; C20orf52; bA353C18.2
Summary
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ROMO1 in Genome Data Viewer
Location:
20q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35699405..35700980)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37420181..37421955)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34287327..34288902)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene copine 1 Neighboring gene RNA binding motif protein 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17790 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34251645-34252150 Neighboring gene Sharpr-MPRA regulatory region 3991 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34252655-34253159 Neighboring gene NFS1 cysteine desulfurase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34286841-34287500 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34287501-34288160 Neighboring gene RNA binding motif protein 39 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17795 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34330085-34330770 Neighboring gene ribosome production factor 2 homolog pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells. Shin JA, et al. Biochem Biophys Res Commun, 2013 Sep 20. PMID 23867822
  2. The rs6060566 of the reactive oxygen species modulator 1 (Romo-1) gene affects Romo-1 expression and the development of diabetic retinopathy in Caucasians with type 2 diabetes. Petrovic MG, et al. Acta Ophthalmol, 2015 Dec. PMID 25824963
  3. Serum reactive oxygen species modulator 1 (Romo1) as a potential diagnostic biomarker for non-small cell lung cancer. Lee SH, et al. Lung Cancer, 2014 Aug. PMID 24951318
  4. Reactive Oxygen Species Modulator 1 (Romo1) Predicts Poor Outcomes in Advanced Non-small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy. Lee SH, et al. Cancer Res Treat, 2017 Jan. PMID 27188201, Free PMC Article
  5. ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics. Norton M, et al. Sci Signal, 2014 Jan 28. PMID 24473195

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effects of ROMO1 on cervical cancer progression.
    Title: The effects of ROMO1 on cervical cancer progression.
  2. Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
    Title: Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
  3. Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
    Title: Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
  4. Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
    Title: Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
  5. The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
    Title: The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
  6. Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
    Title: Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
  7. Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
    Title: Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
  8. Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
    Title: Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
  9. Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
    Title: Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
  10. serum Romo1 levels increase in COPD patients and these levels are associated with lung function, inflammation, and oxidative stress in COPD.
    Title: Increased Serum Romo1 Was Correlated with Lung Function, Inflammation, and Oxidative Stress in Chronic Obstructive Pulmonary Disease.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111180

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replicative senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
reactive oxygen species modulator 1
Names
PCM19
ROS modulator 1
epididymis tissue protein Li 175
glyrichin
mitochondrial targeting GXXXG protein
mitochondrial targeting GxxxG motif protein
protein MGR2 homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080748.3 → NP_542786.1  reactive oxygen species modulator 1

    Status: REVIEWED

    Source sequence(s)
    AK000548, BC105281
    Consensus CDS
    CCDS13264.1
    UniProtKB/Swiss-Prot
    A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
    Related
    ENSP00000363190.3, ENST00000374077.8
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    35699405..35700980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027678.2 → XP_016883167.1  reactive oxygen species modulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
    Related
    ENSP00000363191.1, ENST00000374078.5
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    37420181..37421955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323022.1 → XP_054178997.1  reactive oxygen species modulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60602.1 GenPept UniProtKB/Swiss-Prot:P60602

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