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SRXN1 sulfiredoxin 1 [ Homo sapiens (human) ]

Gene ID: 140809, updated on 1-Jun-2020

Summary

Official Symbol
SRXN1provided by HGNC
Official Full Name
sulfiredoxin 1provided by HGNC
Primary source
HGNC:HGNC:16132
See related
Ensembl:ENSG00000271303 MIM:617583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRX; Npn3; SRX1; C20orf139
Expression
Ubiquitous expression in adrenal (RPKM 21.6), esophagus (RPKM 17.3) and 25 other tissues See more
Orthologs

Genomic context

See SRXN1 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (646615..653200, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (627259..634014, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene uncharacterized LOC107985387 Neighboring gene uncharacterized LOC107985423 Neighboring gene uncharacterized LOC105372491 Neighboring gene scratch family transcriptional repressor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43353

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on a sulfur group of donors IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfiredoxin activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080725.3NP_542763.1  sulfiredoxin-1

    See identical proteins and their annotated locations for NP_542763.1

    Status: VALIDATED

    Source sequence(s)
    AL833944
    Consensus CDS
    CCDS13005.1
    UniProtKB/Swiss-Prot
    Q9BYN0
    Related
    ENSP00000371388.3, ENST00000381962.3
    Conserved Domains (1) summary
    cl02129
    Location:32132
    ParBc; ParB-like nuclease domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    646615..653200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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