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SRXN1 sulfiredoxin 1 [ Homo sapiens (human) ]

Gene ID: 140809, updated on 17-Jan-2024

Summary

Official Symbol
SRXN1provided by HGNC
Official Full Name
sulfiredoxin 1provided by HGNC
Primary source
HGNC:HGNC:16132
See related
Ensembl:ENSG00000271303 MIM:617583; AllianceGenome:HGNC:16132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRX; Npn3; SRX1; C20orf139
Summary
Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 21.6), esophagus (RPKM 17.3) and 25 other tissues See more
Orthologs
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Genomic context

See SRXN1 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (646615..653200, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (690889..697474, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (627259..633844, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:456844-457048 Neighboring gene casein kinase 2 alpha 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:522754-523447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12579 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:524141-524834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:552949-553709 Neighboring gene Sharpr-MPRA regulatory region 14258 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:572175-572398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:591860-592360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:592361-592861 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:596343-597542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:601772-602601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:602602-603430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:614811-615388 Neighboring gene transcription factor 15 Neighboring gene uncharacterized LOC107985423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:642152-642765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:642766-643378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:653674-654187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12583 Neighboring gene Sharpr-MPRA regulatory region 5118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:669184-669764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:669765-670343 Neighboring gene scratch family transcriptional repressor 2 Neighboring gene MPRA-validated peak4111 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:700539-701043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:714587-715087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:749319-749818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:756400-757102 Neighboring gene solute carrier family 52 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ43353

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfiredoxin activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfiredoxin activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfiredoxin-1
Names
sulphiredoxin
NP_542763.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080725.3NP_542763.1  sulfiredoxin-1

    See identical proteins and their annotated locations for NP_542763.1

    Status: VALIDATED

    Source sequence(s)
    AL833944
    Consensus CDS
    CCDS13005.1
    UniProtKB/Swiss-Prot
    B2R543, Q8NDM3, Q96AK6, Q9BYN0
    Related
    ENSP00000371388.4, ENST00000381962.4
    Conserved Domains (1) summary
    cl02129
    Location:32132
    ParBc; ParB-like nuclease domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    646615..653200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    690889..697474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)