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KRT72 keratin 72 [ Homo sapiens (human) ]

Gene ID: 140807, updated on 5-Jul-2020

Summary

Official Symbol
KRT72provided by HGNC
Official Full Name
keratin 72provided by HGNC
Primary source
HGNC:HGNC:28932
See related
Ensembl:ENSG00000170486 MIM:608246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRT6; K6irs; K6IRS2; KRT6IRS2
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]
Expression
Biased expression in testis (RPKM 10.2), skin (RPKM 2.1) and 3 other tissues See more
Orthologs

Genomic context

See KRT72 in Genome Data Viewer
Location:
12q13.13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52585589..52602900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52979373..52995322, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 71 Neighboring gene keratin 74 Neighboring gene keratin 73 Neighboring gene KRT73 antisense RNA 1 Neighboring gene uncharacterized LOC105369772

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 72
Names
CK-72
K72
cytokeratin-72
keratin 6, inner root sheath, 2
keratin 72, type II
keratin protein K6irs
type II inner root sheath-specific keratin-K6irs2
type-II keratin Kb35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012427.1 RefSeqGene

    Range
    5076..20950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146225.2NP_001139697.1  keratin, type II cytoskeletal 72 isoform 1

    See identical proteins and their annotated locations for NP_001139697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK093060, AK293645, BC113686, BX089867
    Consensus CDS
    CCDS8833.1
    UniProtKB/Swiss-Prot
    Q14CN4
    Related
    ENSP00000441160.2, ENST00000537672.6
    Conserved Domains (3) summary
    pfam00038
    Location:124437
    Filament; Intermediate filament protein
    pfam16208
    Location:15121
    Keratin_2_head; Keratin type II head
    cl19219
    Location:233413
    DUF342; Protein of unknown function (DUF342)
  2. NM_001146226.2NP_001139698.1  keratin, type II cytoskeletal 72 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing a 42 aa protein segment compared to isoform 1.
    Source sequence(s)
    AK293645, AY033495, BC113686, BX089867
    Consensus CDS
    CCDS53795.1
    UniProtKB/Swiss-Prot
    Q14CN4
    Related
    ENSP00000346269.4, ENST00000354310.4
    Conserved Domains (2) summary
    pfam00038
    Location:124395
    Filament; Intermediate filament protein
    pfam16208
    Location:15121
    Keratin_2_head; Keratin type II head
  3. NM_080747.3NP_542785.1  keratin, type II cytoskeletal 72 isoform 1

    See identical proteins and their annotated locations for NP_542785.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK293645, AY033495, BC113686, BX089867
    Consensus CDS
    CCDS8833.1
    UniProtKB/Swiss-Prot
    Q14CN4
    Related
    ENSP00000293745.2, ENST00000293745.7
    Conserved Domains (3) summary
    pfam00038
    Location:124437
    Filament; Intermediate filament protein
    pfam16208
    Location:15121
    Keratin_2_head; Keratin type II head
    cl19219
    Location:233413
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52585589..52602900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018836.1XP_016874325.1  keratin, type II cytoskeletal 72 isoform X4

    Conserved Domains (3) summary
    pfam00038
    Location:32345
    Filament; Intermediate filament protein
    pfam16208
    Location:829
    Keratin_2_head; Keratin type II head
    cl19219
    Location:141321
    DUF342; Protein of unknown function (DUF342)
  2. XM_017018834.1XP_016874323.1  keratin, type II cytoskeletal 72 isoform X2

    Conserved Domains (3) summary
    pfam00038
    Location:55368
    Filament; Intermediate filament protein
    pfam16208
    Location:952
    Keratin_2_head; Keratin type II head
    cl19219
    Location:164344
    DUF342; Protein of unknown function (DUF342)
  3. XM_017018835.1XP_016874324.1  keratin, type II cytoskeletal 72 isoform X3

    Conserved Domains (2) summary
    pfam00038
    Location:71365
    Filament; Intermediate filament protein
    cl19219
    Location:161341
    DUF342; Protein of unknown function (DUF342)
  4. XM_017018833.1XP_016874322.1  keratin, type II cytoskeletal 72 isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:77371
    Filament; Intermediate filament protein
    cl19219
    Location:167347
    DUF342; Protein of unknown function (DUF342)
  5. XM_024448846.1XP_024304614.1  keratin, type II cytoskeletal 72 isoform X5

    Conserved Domains (1) summary
    pfam00038
    Location:2249
    Filament; Intermediate filament protein
  6. XM_017018837.1XP_016874326.1  keratin, type II cytoskeletal 72 isoform X6

    Conserved Domains (1) summary
    pfam00038
    Location:1197
    Filament; Intermediate filament protein
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