Il25 interleukin 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il25provided by MGI
Official Full Name: interleukin 25provided by MGI
Primary source: MGI:MGI:2155888
See related: Ensembl:ENSMUSG00000040770 AllianceGenome:MGI:2155888
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-25; Il17e; IL-17e
Summary: Enables cytokine activity. Acts upstream of or within several processes, including eosinophil differentiation; response to fungus; and response to nematode. Predicted to be located in extracellular space. Orthologous to human IL25 (interleukin 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 14; 14 C3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55170152..55173294)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54932695..54935837)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice.
Title: IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice.
IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1.
Title: IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1.
Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation.
Title: Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation.
Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin.
Title: Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin.
IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
Title: IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.
Title: Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.
Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
Title: Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation.
Title: ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation.
IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice.
Title: IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice.
In mice IL-17E induces skin inflammation in vivo, characterized by the expression of innate immune response genes and the recruitment of innate immune cells, particularly neutrophils. Genetic deletion or IL-17E neutralization ameliorated skin inflammation induced by imiquimod application or tape stripping, with reductions in neutrophil and macrophage infiltration in mice.
Title: IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-17E receptor binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 2 cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within eosinophil differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to fungus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to nematode	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-25

Names: interleukin 17E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.