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CRY2 cryptochrome circadian regulator 2 [ Homo sapiens (human) ]

Gene ID: 1408, updated on 18-May-2019

Summary

Official Symbol
CRY2provided by HGNC
Official Full Name
cryptochrome circadian regulator 2provided by HGNC
Primary source
HGNC:HGNC:2385
See related
Ensembl:ENSG00000121671 MIM:603732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCRY2; PHLL2
Summary
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues See more
Orthologs

Genomic context

See CRY2 in Genome Data Viewer
Location:
11p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (45847118..45883248)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45868669..45904799)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2716 Neighboring gene solute carrier family 35 member C1 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene chromosome 11 open reading frame 94

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from BioSystems

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rhythm, organism-specific biosystem (from KEGG)
    Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rhythm, conserved biosystem (from KEGG)
    Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
  • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
    Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10332, KIAA0658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT DNA (6-4) photolyase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
blue light photoreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT deoxyribodipyrimidine photo-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
blue light signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucocorticoid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT photoreactive repair IDA
Inferred from Direct Assay
more info
PubMed 
protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sodium-dependent phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
response to activity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cryptochrome-2
Names
cryptochrome 2 (photolyase-like)
cryptochrome circadian clock 2
growth-inhibiting protein 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127457.2NP_001120929.1  cryptochrome-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus.
    Source sequence(s)
    AC068385, AI375851, BC041814, DC330290
    Consensus CDS
    CCDS44576.1
    UniProtKB/Swiss-Prot
    Q49AN0
    Related
    ENSP00000397419.2, ENST00000417225.6
    Conserved Domains (3) summary
    COG0415
    Location:2449
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam00875
    Location:11111
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:171444
    FAD_binding_7; FAD binding domain of DNA photolyase
  2. NM_021117.5NP_066940.3  cryptochrome-2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate first exon which contains the predicted translation start site; the resulting protein has a distinct N-terminus.
    Source sequence(s)
    AC068385, AK302865, BC041814
    Consensus CDS
    CCDS7915.2
    Related
    ENSP00000478187.1, ENST00000616623.4
    Conserved Domains (2) summary
    COG0415
    Location:22510
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:307505
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    45847118..45883248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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