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Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta [ Mus musculus (house mouse) ]

Gene ID: 140781, updated on 10-Jan-2023

Summary

Official Symbol
Myh7provided by MGI
Official Full Name
myosin, heavy polypeptide 7, cardiac muscle, betaprovided by MGI
Primary source
MGI:MGI:2155600
See related
Ensembl:ENSMUSG00000053093 AllianceGenome:MGI:2155600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-MHC; Myhcb; MyHC-I; Myhc-b; betaMHC; beta-MHC; myHC-beta; myHC-slow; MYH-beta/slow
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and transition between fast and slow fiber. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including diaphragm; eye; heart; musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 264.5) See more
Orthologs
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Genomic context

See Myh7 in Genome Data Viewer
Location:
14 C3; 14 28.01 cM
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55208141..55232083, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54970684..54994626, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 6, cardiac muscle, alpha Neighboring gene microRNA 208a Neighboring gene predicted gene, 52092 Neighboring gene myosin heavy chain associated RNA transcript Neighboring gene microRNA 208b Neighboring gene predicted gene, 31251 Neighboring gene VISTA enhancer mm771 Neighboring gene VISTA enhancer mm1288

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adult heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adult heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle filament sliding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of slow-twitch skeletal muscle fiber contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of the force of skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myosin filament ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myosin-7
Names
myosin heavy chain 7
myosin heavy chain, cardiac muscle, fetal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361607.1NP_001348536.1  myosin-7

    Status: VALIDATED

    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS27106.1
    UniProtKB/Swiss-Prot
    Q3TZN2
    UniProtKB/TrEMBL
    A0A6P5QZF1, B2RXX9
    Related
    ENSMUSP00000126840.2, ENSMUST00000168485.8
    Conserved Domains (3) summary
    COG5022
    Location:371432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:11731930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99766
    MYSc_class_II; class II myosins, motor domain
  2. NM_080728.3NP_542766.1  myosin-7

    See identical proteins and their annotated locations for NP_542766.1

    Status: VALIDATED

    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS27106.1
    UniProtKB/Swiss-Prot
    Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    A0A6P5QZF1, B2RXX9
    Related
    ENSMUSP00000099867.4, ENSMUST00000102803.11
    Conserved Domains (3) summary
    COG5022
    Location:371432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:11731930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99766
    MYSc_class_II; class II myosins, motor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55208141..55232083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158456.1XP_036014349.1  myosin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TZN2
    UniProtKB/TrEMBL
    A0A6P5QZF1, B2RXX9
    Conserved Domains (3) summary
    COG5022
    Location:371432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:11731930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99766
    MYSc_class_II; class II myosins, motor domain
  2. XM_017315841.3XP_017171330.1  myosin-7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TZN2, Q91Z83
    UniProtKB/TrEMBL
    A0A6P5QZF1, B2RXX9
    Conserved Domains (3) summary
    COG5022
    Location:371432
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:11731930
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01377
    Location:99766
    MYSc_class_II; class II myosins, motor domain