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Fabp3 fatty acid binding protein 3, muscle and heart [ Mus musculus (house mouse) ]

Gene ID: 14077, updated on 22-Jan-2023

Summary

Official Symbol
Fabp3provided by MGI
Official Full Name
fatty acid binding protein 3, muscle and heartprovided by MGI
Primary source
MGI:MGI:95476
See related
Ensembl:ENSMUSG00000028773 AllianceGenome:MGI:95476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdgi; Fabph1; Fabph4; H-FABP; Fabph-1; Fabph-4
Summary
Predicted to enable cytoskeletal protein binding activity; fatty acid binding activity; and long-chain fatty acid transporter activity. Involved in several processes, including lipid homeostasis; lipid transport; and positive regulation of long-chain fatty acid import into cell. Acts upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 2334.3) and placenta adult (RPKM 178.9) See more
Orthologs
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Genomic context

See Fabp3 in Genome Data Viewer
Location:
4 D2.2; 4 63.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130202531..130209256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130308738..130315463)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46724 Neighboring gene serine incorporator 2 Neighboring gene predicted gene, 34957 Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074 Neighboring gene small nuclear ribonucleoprotein 40 (U5)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables icosatetraenoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables oleic acid binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fatty acid-binding protein, heart
Names
fatty acid binding protein heart 1
fatty acid binding protein heart 4
fatty acid-binding protein 3
heart-type fatty acid-binding protein
mammary-derived growth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010174.2NP_034304.1  fatty acid-binding protein, heart

    See identical proteins and their annotated locations for NP_034304.1

    Status: VALIDATED

    Source sequence(s)
    AL772297
    Consensus CDS
    CCDS18709.1
    UniProtKB/Swiss-Prot
    P11404, Q91W23
    UniProtKB/TrEMBL
    A0A3Q8I9D6, A0A8C6ILB9, Q5EBJ0
    Related
    ENSMUSP00000070709.8, ENSMUST00000070532.8
    Conserved Domains (1) summary
    pfam00061
    Location:6132
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130202531..130209256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)