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DYNLL2 dynein light chain LC8-type 2 [ Homo sapiens (human) ]

Gene ID: 140735, updated on 8-Jul-2021

Summary

Official Symbol
DYNLL2provided by HGNC
Official Full Name
dynein light chain LC8-type 2provided by HGNC
Primary source
HGNC:HGNC:24596
See related
Ensembl:ENSG00000264364 MIM:608942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dlc2; DNCL1B; RSPH22
Expression
Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues See more
Orthologs
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Genomic context

See DYNLL2 in Genome Data Viewer
Location:
17q22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (58083419..58095542)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56160780..56172903)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371840 Neighboring gene DYNLL2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 5901 Neighboring gene Sharpr-MPRA regulatory region 5260 Neighboring gene olfactory receptor family 4 subfamily D member 1 Neighboring gene msh homeobox 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC17810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary tip TAS
Traceable Author Statement
more info
 
located_in cilium TAS
Traceable Author Statement
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of myosin V complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein light chain 2, cytoplasmic
Names
8 kDa dynein light chain b
DLC8b
radial spoke 22 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080677.3NP_542408.1  dynein light chain 2, cytoplasmic

    See identical proteins and their annotated locations for NP_542408.1

    Status: VALIDATED

    Source sequence(s)
    AC015813, BC010744, BF528423, CN280282, DA140058, DB022843
    Consensus CDS
    CCDS11601.1
    UniProtKB/Swiss-Prot
    Q96FJ2
    Related
    ENSP00000477310.1, ENST00000579991.3
    Conserved Domains (1) summary
    cd21452
    Location:588
    DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    58083419..58095542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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