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SOGA1 suppressor of glucose, autophagy associated 1 [ Homo sapiens (human) ]

Gene ID: 140710, updated on 23-Nov-2021

Summary

Official Symbol
SOGA1provided by HGNC
Official Full Name
suppressor of glucose, autophagy associated 1provided by HGNC
Primary source
HGNC:HGNC:16111
See related
Ensembl:ENSG00000149639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOGA; KIAA0889; C20orf117
Expression
Ubiquitous expression in thyroid (RPKM 9.7), brain (RPKM 6.2) and 22 other tissues See more
Orthologs
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Genomic context

See SOGA1 in Genome Data Viewer
Location:
20q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (36777447..36863538, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35405850..35491941, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene NDRG family member 3 Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene RNA, 7SL, cytoplasmic 156, pseudogene Neighboring gene TBC/LysM-associated domain containing 2 Neighboring gene SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44670, KIAA0889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein SOGA1
Names
SOGA family member 1
suppressor of glucose by autophagy
suppressor of glucose from autophagy
suppressor of glucose, autophagy-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080627.4NP_542194.2  protein SOGA1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL079335, AL132768, AL391602, BQ027014
    Consensus CDS
    CCDS54459.1
    UniProtKB/Swiss-Prot
    O94964
    Related
    ENSP00000237536.4, ENST00000237536.9
    Conserved Domains (2) summary
    pfam11365
    Location:380474
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:10691206
    DUF4482; Domain of unknown function (DUF4482)
  2. NM_199181.3NP_954650.2  protein SOGA1 isoform 2

    See identical proteins and their annotated locations for NP_954650.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, and a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK126630, AL935080, BF944938, BQ027014
    Consensus CDS
    CCDS46598.1
    UniProtKB/Swiss-Prot
    O94964
    UniProtKB/TrEMBL
    X6R3R3
    Related
    ENSP00000279034.5, ENST00000279034.10
    Conserved Domains (2) summary
    pfam11365
    Location:142236
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:831968
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36777447..36863538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152257.1: Suppressed sequence

    Description
    NM_152257.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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