U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SAMD10 sterile alpha motif domain containing 10 [ Homo sapiens (human) ]

Gene ID: 140700, updated on 17-Sep-2024

Summary

Official Symbol
SAMD10provided by HGNC
Official Full Name
sterile alpha motif domain containing 10provided by HGNC
Primary source
HGNC:HGNC:16129
See related
Ensembl:ENSG00000130590 AllianceGenome:HGNC:16129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ591C20; C20orf136; dJ591C20.7
Summary
Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 2.3), stomach (RPKM 1.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SAMD10 in Genome Data Viewer
Location:
20q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63974116..63980144, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65793877..65799906, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62605469..62610995, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62573671-62574384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62574385-62575096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580108-62580646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580647-62581185 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62581186-62581724 Neighboring gene microRNA 647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62587955-62588842 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62588843-62589728 Neighboring gene zinc finger protein 512B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62599635-62600172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62600173-62600708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13196 Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62610429-62610944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13198 Neighboring gene pre-mRNA processing factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62631004-62631506 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62636447-62636619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62642795-62643994 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:62648052-62649251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62667815-62668408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62668409-62669002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13201 Neighboring gene chromosome 20 open reading frame 204

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
sterile alpha motif domain-containing protein 10
Names
D930033N23Rik
SAM domain-containing protein 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080621.5NP_542188.1  sterile alpha motif domain-containing protein 10

    See identical proteins and their annotated locations for NP_542188.1

    Status: VALIDATED

    Source sequence(s)
    BC067362, BM839907
    Consensus CDS
    CCDS13549.1
    UniProtKB/Swiss-Prot
    Q9BYL1
    Related
    ENSP00000358902.3, ENST00000369886.8
    Conserved Domains (1) summary
    cd09510
    Location:113187
    SAM_aveugle-like; SAM domain of aveugle-like subfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63974116..63980144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528565.3XP_011526867.2  sterile alpha motif domain-containing protein 10 isoform X1

  2. XM_006723705.4XP_006723768.1  sterile alpha motif domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    cd09510
    Location:119193
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:121188
    SAM; Sterile alpha motif
  3. XM_005260199.5XP_005260256.1  sterile alpha motif domain-containing protein 10 isoform X2

    Conserved Domains (2) summary
    cd09510
    Location:152226
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:154221
    SAM; Sterile alpha motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65793877..65799906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323004.1XP_054178979.1  sterile alpha motif domain-containing protein 10 isoform X1

  2. XM_054323005.1XP_054178980.1  sterile alpha motif domain-containing protein 10 isoform X2

  3. XM_054323007.1XP_054178982.1  sterile alpha motif domain-containing protein 10 isoform X4

    UniProtKB/Swiss-Prot
    Q9BYL1
  4. XM_054323006.1XP_054178981.1  sterile alpha motif domain-containing protein 10 isoform X3