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SAMD10 sterile alpha motif domain containing 10 [ Homo sapiens (human) ]

Gene ID: 140700, updated on 13-May-2022

Summary

Official Symbol
SAMD10provided by HGNC
Official Full Name
sterile alpha motif domain containing 10provided by HGNC
Primary source
HGNC:HGNC:16129
See related
Ensembl:ENSG00000130590 AllianceGenome:HGNC:16129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ591C20; C20orf136; dJ591C20.7
Summary
Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 2.3), stomach (RPKM 1.9) and 24 other tissues See more
Orthologs
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Genomic context

See SAMD10 in Genome Data Viewer
Location:
20q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63974116..63980144, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65793877..65799404, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62605469..62610995, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene microRNA 647 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene zinc finger protein 512B Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene pre-mRNA processing factor 6 Neighboring gene chromosome 20 open reading frame 204

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sterile alpha motif domain-containing protein 10
Names
D930033N23Rik
SAM domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080621.5NP_542188.1  sterile alpha motif domain-containing protein 10

    See identical proteins and their annotated locations for NP_542188.1

    Status: VALIDATED

    Source sequence(s)
    BC067362, BM839907
    Consensus CDS
    CCDS13549.1
    UniProtKB/Swiss-Prot
    Q9BYL1
    Related
    ENSP00000358902.3, ENST00000369886.8
    Conserved Domains (1) summary
    cd09510
    Location:113187
    SAM_aveugle-like; SAM domain of aveugle-like subfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63974116..63980144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528565.3XP_011526867.2  sterile alpha motif domain-containing protein 10 isoform X1

  2. XM_006723705.4XP_006723768.1  sterile alpha motif domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    cd09510
    Location:119193
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:121188
    SAM; Sterile alpha motif
  3. XM_005260199.5XP_005260256.1  sterile alpha motif domain-containing protein 10 isoform X2

    Conserved Domains (2) summary
    cd09510
    Location:152226
    SAM_aveugle-like; SAM domain of aveugle-like subfamily
    smart00454
    Location:154221
    SAM; Sterile alpha motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65793877..65799404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)