U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnm1 dynamin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140694, updated on 5-Jan-2023

Summary

Official Symbol
Dnm1provided by RGD
Official Full Name
dynamin 1provided by RGD
Primary source
RGD:71096
See related
Ensembl:ENSRNOG00000033835 AllianceGenome:RGD:71096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dnm
Summary
Enables several functions, including D2 dopamine receptor binding activity; SH3 domain binding activity; and nitric-oxide synthase binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in several cellular components, including Golgi apparatus; synaptic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31. Orthologous to human DNM1 (dynamin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 601.1), Adrenal (RPKM 55.1) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dnm1 in Genome Data Viewer
Location:
3p12
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15604782..15648654, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11338081..11382043, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene SWI5 homologous recombination repair protein Neighboring gene golgin A2 Neighboring gene U1 spliceosomal RNA Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D2 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amyloid-beta IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of membrane coat ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
is_active_in photoreceptor ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in varicosity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynamin-1
Names
B-dynamin
D100
dynamin, brain
NP_542420.1
XP_038960068.1
XP_038960069.1
XP_038960070.1
XP_038960071.1
XP_038960072.1
XP_038960073.1
XP_038960075.1
XP_038960076.1
XP_038960077.1
XP_038960078.1
XP_038960079.1
XP_038960080.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080689.5NP_542420.1  dynamin-1

    See identical proteins and their annotated locations for NP_542420.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000115
    UniProtKB/Swiss-Prot
    P21575
    Related
    ENSRNOP00000060845.3, ENSRNOT00000064039.5
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    15604782..15648654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104148.1XP_038960076.1  dynamin-1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6ALW7
    Related
    ENSRNOP00000095659.1, ENSRNOT00000110861.1
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:743860
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:653741
    GED; Dynamin GTPase effector domain
  2. XM_039104147.1XP_038960075.1  dynamin-1 isoform X7

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:743860
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:653741
    GED; Dynamin GTPase effector domain
  3. XM_039104143.1XP_038960071.1  dynamin-1 isoform X4

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
    NF033913
    Location:710863
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  4. XM_039104141.1XP_038960069.1  dynamin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AHJ0
    Related
    ENSRNOP00000092707.1, ENSRNOT00000118464.1
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  5. XM_039104145.1XP_038960073.1  dynamin-1 isoform X6

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  6. XM_039104152.1XP_038960080.1  dynamin-1 isoform X11

    Related
    ENSRNOP00000091634.1, ENSRNOT00000102787.1
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  7. XM_039104142.1XP_038960070.1  dynamin-1 isoform X3

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
    NF033913
    Location:710863
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  8. XM_039104140.1XP_038960068.1  dynamin-1 isoform X1

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  9. XM_039104144.1XP_038960072.1  dynamin-1 isoform X5

    UniProtKB/Swiss-Prot
    P21575
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  10. XM_039104149.1XP_038960077.1  dynamin-1 isoform X9

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747848
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  11. XM_039104150.1XP_038960078.1  dynamin-1 isoform X10

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  12. XM_039104151.1XP_038960079.1  dynamin-1 isoform X10

    Related
    ENSRNOP00000041582.6, ENSRNOT00000047921.6
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain

RNA

  1. XR_005501757.1 RNA Sequence

  2. XR_005501758.1 RNA Sequence

  3. XR_005501756.1 RNA Sequence