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TRIM69 tripartite motif containing 69 [ Homo sapiens (human) ]

Gene ID: 140691, updated on 17-Jun-2019

Summary

Official Symbol
TRIM69provided by HGNC
Official Full Name
tripartite motif containing 69provided by HGNC
Primary source
HGNC:HGNC:17857
See related
Ensembl:ENSG00000185880 MIM:616017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Trif; HSD34; RNF36; HSD-34
Summary
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 19.8) and brain (RPKM 1.8) See more
Orthologs

Genomic context

See TRIM69 in Genome Data Viewer
Location:
15q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (44736528..44767827)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45028314..45060027)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 10393 Neighboring gene ring finger protein 4 pseudogene Neighboring gene beta-2-microglobulin Neighboring gene sorbitol dehydrogenase 2, pseudogene Neighboring gene uncharacterized LOC105370798 Neighboring gene RNA, U1 small nuclear 119, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM69
Names
RFP-like domain-containing protein trimless
RING-type E3 ubiquitin transferase TRIM69
ring finger protein 36
NP_001288073.1
NP_001288074.1
NP_001288075.1
NP_542783.2
NP_892030.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033935.1 RefSeqGene

    Range
    5001..36468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301144.2NP_001288073.1  E3 ubiquitin-protein ligase TRIM69 isoform c

    See identical proteins and their annotated locations for NP_001288073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks an alternate exon and uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (c, also known as TRIMLESS alpha) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC122108, AF302088, BI827618, DB524904
    Consensus CDS
    CCDS73719.1
    UniProtKB/Swiss-Prot
    Q86WT6
    Related
    ENSP00000453549.1, ENST00000560442.5
    Conserved Domains (1) summary
    cd15818
    Location:107293
    SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
  2. NM_001301145.2NP_001288074.1  E3 ubiquitin-protein ligase TRIM69 isoform d

    See identical proteins and their annotated locations for NP_001288074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks an alternate exon and uses two alternate splice sites, and it thus differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an in-frame segment in the central coding region, compared to variant a. The encoded isoform (d, also known as TRIMLESS beta) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC122108, AF302089, BI827618, DB524904
    Consensus CDS
    CCDS76746.1
    UniProtKB/Swiss-Prot
    Q86WT6
    Related
    ENSP00000453332.1, ENST00000558329.5
    Conserved Domains (1) summary
    cd15818
    Location:90276
    SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
  3. NM_001301146.2NP_001288075.1  E3 ubiquitin-protein ligase TRIM69 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant a, resulting in an isoform (e) that is shorter than isoform a.
    Source sequence(s)
    AC122108, AF302088, BI465168, BI827618, DB524904
    Consensus CDS
    CCDS76745.1
    UniProtKB/Swiss-Prot
    Q86WT6
    UniProtKB/TrEMBL
    H0YL66
    Related
    ENSP00000453077.1, ENST00000561043.5
    Conserved Domains (1) summary
    cd15818
    Location:74260
    SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
  4. NM_080745.5NP_542783.2  E3 ubiquitin-protein ligase TRIM69 isoform b

    See identical proteins and their annotated locations for NP_542783.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC122108, BC033314, BI827618, DB524904
    Consensus CDS
    CCDS10114.1
    UniProtKB/Swiss-Prot
    Q86WT6
    Related
    ENSP00000342922.4, ENST00000338264.8
    Conserved Domains (1) summary
    cd15818
    Location:152338
    SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
  5. NM_182985.5NP_892030.3  E3 ubiquitin-protein ligase TRIM69 isoform a

    See identical proteins and their annotated locations for NP_892030.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC122108, AF302088, AY305385, BI827618, DB524904
    Consensus CDS
    CCDS32220.1
    UniProtKB/Swiss-Prot
    Q86WT6
    Related
    ENSP00000332284.3, ENST00000329464.9
    Conserved Domains (3) summary
    cd15818
    Location:311497
    SPRY_PRY_TRIM69; PRY/SPRY domain in tripartite motif-binding protein 69 (TRIM69), also known as RING finger protein 36 (RNF36)
    cl17238
    Location:4181
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:168299
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    44736528..44767827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187605.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    59905..91198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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