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WFDC3 WAP four-disulfide core domain 3 [ Homo sapiens (human) ]

Gene ID: 140686, updated on 5-Aug-2022

Summary

Official Symbol
WFDC3provided by HGNC
Official Full Name
WAP four-disulfide core domain 3provided by HGNC
Primary source
HGNC:HGNC:15957
See related
Ensembl:ENSG00000124116 AllianceGenome:HGNC:15957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP14; dJ447F3.3
Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 19.8) See more
Orthologs
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Genomic context

See WFDC3 in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45774213..45791883, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47510745..47528411, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44402852..44420522, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type 5, pseudogene Neighboring gene uncharacterized LOC124904915 Neighboring gene Sharpr-MPRA regulatory region 12827 Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene deoxynucleotidyltransferase terminal interacting protein 1 Neighboring gene ubiquitin conjugating enzyme E2 C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WAP four-disulfide core domain protein 3
Names
protease inhibitor WAP14
putative protease inhibitor WAP14
whey acidic protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080614.2NP_542181.1  WAP four-disulfide core domain protein 3 precursor

    See identical proteins and their annotated locations for NP_542181.1

    Status: REVIEWED

    Source sequence(s)
    AL050348
    Consensus CDS
    CCDS33478.1
    UniProtKB/Swiss-Prot
    Q8IUB2, Q9BQP4
    Related
    ENSP00000243938.4, ENST00000243938.9
    Conserved Domains (1) summary
    pfam00095
    Location:168206
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45774213..45791883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528553.3XP_011526855.1  WAP four-disulfide core domain protein 3 isoform X1

    Conserved Domains (1) summary
    pfam00095
    Location:174212
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47510745..47528411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181522.1: Suppressed sequence

    Description
    NM_181522.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_181525.1: Suppressed sequence

    Description
    NM_181525.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_181530.1: Suppressed sequence

    Description
    NM_181530.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.