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SLC32A1 solute carrier family 32 member 1 [ Homo sapiens (human) ]

Gene ID: 140679, updated on 8-Jul-2021

Summary

Official Symbol
SLC32A1provided by HGNC
Official Full Name
solute carrier family 32 member 1provided by HGNC
Primary source
HGNC:HGNC:11018
See related
Ensembl:ENSG00000101438 MIM:616440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VGAT; VIAAT
Summary
The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 6.2) See more
Orthologs
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Genomic context

See SLC32A1 in Genome Data Viewer
Location:
20q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38724486..38729372)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37353129..37358015)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene VISTA enhancer hs2620 Neighboring gene RN7SK pseudogene 173 Neighboring gene actin related protein 5 Neighboring gene protein phosphatase 1 regulatory subunit 16B Neighboring gene RNA, 7SL, cytoplasmic 116, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gamma-aminobutyric acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in glycine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter secretion TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in cell tip IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cone cell pedicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in inhibitory synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vesicular inhibitory amino acid transporter
Names
GABA and glycine transporter
hVIAAT
solute carrier family 32 (GABA vesicular transporter), member 1
vesicular GABA transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080552.3NP_542119.1  vesicular inhibitory amino acid transporter

    See identical proteins and their annotated locations for NP_542119.1

    Status: REVIEWED

    Source sequence(s)
    BC053582, BI488536
    Consensus CDS
    CCDS13307.1
    UniProtKB/Swiss-Prot
    Q9H598
    Related
    ENSP00000217420.1, ENST00000217420.2
    Conserved Domains (1) summary
    pfam01490
    Location:115512
    Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38724486..38729372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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