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Ap2b1 adaptor related protein complex 2 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140670, updated on 10-Oct-2019

Summary

Official Symbol
Ap2b1provided by RGD
Official Full Name
adaptor related protein complex 2 subunit beta 1provided by RGD
Primary source
RGD:71048
See related
Ensembl:ENSRNOG00000061543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
subunit of the clathrin-associated protein complex 2 [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 391.0), Brain (RPKM 322.3) and 9 other tissues See more
Orthologs

Genomic context

See Ap2b1 in Genome Data Viewer
Location:
10q26
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70516462..70621973)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (67045800..67146677)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (71035406..71067828) , (71068935..71083997)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S27-like Neighboring gene uncharacterized LOC100912181 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aorta development IEA
Inferred from Electronic Annotation
more info
 
aorta development ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiac septum development ISO
Inferred from Sequence Orthology
more info
PubMed 
clathrin coat assembly IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
coronary vasculature development ISO
Inferred from Sequence Orthology
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
AP-2 adaptor complex IEA
Inferred from Electronic Annotation
more info
 
AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
AP-type membrane coat adaptor complex TAS
Traceable Author Statement
more info
PubMed 
clathrin coat IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AP-2 complex subunit beta
Names
AP-1 complex subunit beta-1-like
AP105B
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit beta
adaptor-related protein complex 2, beta 1 subunit
beta-2-adaptin
beta-adaptin
beta2-adaptin
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080583.1NP_542150.1  AP-2 complex subunit beta

    See identical proteins and their annotated locations for NP_542150.1

    Status: PROVISIONAL

    Source sequence(s)
    M77246
    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Related
    ENSRNOP00000070905.1, ENSRNOT00000088198.1
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    70516462..70621973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767937.2XP_008766159.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766159.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  2. XM_017596973.1XP_017452462.1  AP-2 complex subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  3. XM_008767938.1XP_008766160.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766160.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  4. XM_008767936.2XP_008766158.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766158.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  5. XM_008767935.2XP_008766157.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766157.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  6. XM_008767939.2XP_008766161.1  AP-2 complex subunit beta isoform X2

    See identical proteins and their annotated locations for XP_008766161.1

    UniProtKB/Swiss-Prot
    P62944
    Related
    ENSRNOP00000072290.1, ENSRNOT00000085799.1
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    67045800..67146677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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