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cyp1a cytochrome P450, family 1, subfamily A [ Danio rerio (zebrafish) ]

Gene ID: 140634, updated on 9-Dec-2024

Summary

Official Symbol
cyp1aprovided by ZNC
Official Full Name
cytochrome P450, family 1, subfamily Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011219-1
See related
Ensembl:ENSDARG00000098315 AllianceGenome:ZFIN:ZDB-GENE-011219-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cyp1a1; zfCYP1A; wu:fb63b04; zgc:109747
Summary
Predicted to enable monooxygenase activity. Acts upstream of or within cellular response to organic cyclic compound and cellular response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1) and CYP1A2 (cytochrome P450 family 1 subfamily A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See cyp1a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5588068..5598958, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5738733..5749620, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene NAD(P) transhydrogenase, mitochondrial Neighboring gene AFG2 AAA ATPase homolog B Neighboring gene nicotinamide nucleotide transhydrogenase 2 Neighboring gene unc-51 like kinase 3 Neighboring gene uncharacterized LOC101884251

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 1A1
Names
cytochrome P450, subfamily I, polypeptide 1
NP_571954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131879.2NP_571954.1  cytochrome P450 1A1

    See identical proteins and their annotated locations for NP_571954.1

    Status: VALIDATED

    Source sequence(s)
    AI496734, CF997194, CU462829, EH454923, EH525844
    UniProtKB/TrEMBL
    A0A8N7XJK0, Q8QGS5, Q8UW07
    Related
    ENSDARP00000139599.1, ENSDART00000161538.2
    Conserved Domains (1) summary
    pfam00067
    Location:46499
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    5588068..5598958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)