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Ube4a ubiquitination factor E4A [ Mus musculus (house mouse) ]

Gene ID: 140630, updated on 9-Mar-2023

Summary

Official Symbol
Ube4aprovided by MGI
Official Full Name
ubiquitination factor E4Aprovided by MGI
Primary source
MGI:MGI:2154580
See related
Ensembl:ENSMUSG00000059890 AllianceGenome:MGI:2154580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UFD2b; 4732444G18Rik; 9930123J21Rik
Summary
Enables ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in cytoplasm. Is expressed in ganglia; medulla oblongata basal plate; thymus primordium; ventral grey horn; and vibrissa. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 8.1), whole brain E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ube4a in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44834425..44877021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44923127..44965615, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26249 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G Neighboring gene predicted gene, 30934 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A pseudogene Neighboring gene CD3 antigen, gamma polypeptide Neighboring gene CD3 antigen, delta polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin conjugation factor E4 A
Names
ubiquitination factor E4A, UFD2 homolog
NP_001333627.1
NP_001348004.1
NP_001348005.1
NP_663375.3
XP_006510065.1
XP_006510066.1
XP_011240696.1
XP_011240697.1
XP_011240698.1
XP_030099909.1
XP_030099910.1
XP_030099911.1
XP_030099912.1
XP_036010503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346698.1NP_001333627.1  ubiquitin conjugation factor E4 A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166048
    Consensus CDS
    CCDS85670.1
    UniProtKB/TrEMBL
    A0A8C6GTI5, G3X9Y5
    Conserved Domains (2) summary
    cd16657
    Location:10091078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349990
    Ufd2P_core; Ubiquitin elongating factor core
  2. NM_001361075.1NP_001348004.1  ubiquitin conjugation factor E4 A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166048, AK028850
    Consensus CDS
    CCDS90555.1
    UniProtKB/TrEMBL
    Q8VDS1
    Related
    ENSMUSP00000149791.2, ENSMUST00000138559.9
  3. NM_001361076.1NP_001348005.1  ubiquitin conjugation factor E4 A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166048
    Conserved Domains (1) summary
    pfam10408
    Location:253846
    Ufd2P_core; Ubiquitin elongating factor core
  4. NM_145400.3NP_663375.3  ubiquitin conjugation factor E4 A isoform 1

    See identical proteins and their annotated locations for NP_663375.3

    Status: VALIDATED

    Source sequence(s)
    AC166048, AK172893, CN705350
    Consensus CDS
    CCDS23122.2
    UniProtKB/Swiss-Prot
    E9Q735
    UniProtKB/TrEMBL
    A0A8C6GSS2, Q6A0C5
    Related
    ENSMUSP00000113346.2, ENSMUST00000117506.9
    Conserved Domains (2) summary
    pfam10408
    Location:330933
    Ufd2P_core; Ubiquitin elongating factor core
    cd16657
    Location:9521021
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins

RNA

  1. NR_153962.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166048
    Related
    ENSMUST00000154287.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44834425..44877021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510002.4XP_006510065.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_006510065.1

    UniProtKB/TrEMBL
    A0A8C6GTI5, G3X9Y5
    Related
    ENSMUSP00000112632.2, ENSMUST00000117549.8
    Conserved Domains (2) summary
    cd16657
    Location:10091078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349990
    Ufd2P_core; Ubiquitin elongating factor core
  2. XM_030244049.1XP_030099909.1  ubiquitin conjugation factor E4 A isoform X2

    Conserved Domains (2) summary
    cd16657
    Location:9901059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330971
    Ufd2P_core; Ubiquitin elongating factor core
  3. XM_030244052.1XP_030099912.1  ubiquitin conjugation factor E4 A isoform X4

    Conserved Domains (2) summary
    cd16657
    Location:913982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253894
    Ufd2P_core; Ubiquitin elongating factor core
  4. XM_006510003.5XP_006510066.1  ubiquitin conjugation factor E4 A isoform X2

    See identical proteins and their annotated locations for XP_006510066.1

    Conserved Domains (2) summary
    cd16657
    Location:9901059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330971
    Ufd2P_core; Ubiquitin elongating factor core
  5. XM_011242395.4XP_011240697.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_011240697.1

    UniProtKB/TrEMBL
    A0A8C6GTI5, G3X9Y5
    Conserved Domains (2) summary
    cd16657
    Location:10091078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349990
    Ufd2P_core; Ubiquitin elongating factor core
  6. XM_011242396.4XP_011240698.1  ubiquitin conjugation factor E4 A isoform X2

    See identical proteins and their annotated locations for XP_011240698.1

    Conserved Domains (2) summary
    cd16657
    Location:9901059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330971
    Ufd2P_core; Ubiquitin elongating factor core
  7. XM_011242394.4XP_011240696.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_011240696.1

    UniProtKB/TrEMBL
    A0A8C6GTI5, G3X9Y5
    Conserved Domains (2) summary
    cd16657
    Location:10091078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349990
    Ufd2P_core; Ubiquitin elongating factor core
  8. XM_030244050.2XP_030099910.1  ubiquitin conjugation factor E4 A isoform X4

    Conserved Domains (2) summary
    cd16657
    Location:913982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253894
    Ufd2P_core; Ubiquitin elongating factor core
  9. XM_030244051.2XP_030099911.1  ubiquitin conjugation factor E4 A isoform X4

    Conserved Domains (2) summary
    cd16657
    Location:913982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253894
    Ufd2P_core; Ubiquitin elongating factor core
  10. XM_036154610.1XP_036010503.1  ubiquitin conjugation factor E4 A isoform X3

    Conserved Domains (2) summary
    pfam10408
    Location:349990
    Ufd2P_core; Ubiquitin elongating factor core
    cl17238
    Location:10091044
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain