atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aticprovided by ZNC
Official Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011212-4
See related: Ensembl:ENSDARG00000016706 AllianceGenome:ZFIN:ZDB-GENE-011212-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb72; id:ibd1333; wu:fb50b10; wu:fb58a11; wu:fi76g09; wu:fy77g01
Summary: Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; immature eye; nervous system; neural crest; and yolk. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, May 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (6887462..6905739)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (5485853..5503665)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb58a11 (e-PCR)
- UniSTS:187241

atic (e-PCR), detects polymorphism
- UniSTS:205680

fi76g09.x1 (e-PCR)
- UniSTS:198020

fc76e11.x1 (e-PCR)
- UniSTS:194483

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bifunctional purine biosynthesis protein ATIC

NP_001076265.2

EC 3.5.4.10

XP_073807954.1

EC 3.5.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082796.2 → NP_001076265.2 bifunctional purine biosynthesis protein ATIC

See identical proteins and their annotated locations for NP_001076265.2

Status: PROVISIONAL

Source sequence(s)

BC163887

UniProtKB/TrEMBL

B3DKL0

Related

ENSDARP00000024082.9, ENSDART00000022307.10

Conserved Domains (3) summary

PRK07106
Location:202 → 590

PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional

COG0138
Location:6 → 590

PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]

cd01421
Location:6 → 192

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...