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atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [ Danio rerio (zebrafish) ]

Gene ID: 140622, updated on 19-Jun-2024

Summary

Official Symbol
aticprovided by ZNC
Official Full Name
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011212-4
See related
Ensembl:ENSDARG00000016706 AllianceGenome:ZFIN:ZDB-GENE-011212-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb72; id:ibd1333; wu:fb50b10; wu:fb58a11; wu:fi76g09; wu:fy77g01
Summary
Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; immature eye; nervous system; neural crest; and yolk. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See atic in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (5485853..5503665)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (4788048..4805860)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene motor neuron and pancreas homeobox 2b Neighboring gene fibronectin 1b Neighboring gene carboxypeptidase O

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables IMP cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables IMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
bifunctional purine biosynthesis protein PURH
NP_001076265.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082796.2NP_001076265.2  bifunctional purine biosynthesis protein PURH

    See identical proteins and their annotated locations for NP_001076265.2

    Status: PROVISIONAL

    Source sequence(s)
    BC163887
    UniProtKB/TrEMBL
    B3DKL0
    Related
    ENSDARP00000024082.9, ENSDART00000022307.10
    Conserved Domains (3) summary
    PRK07106
    Location:202590
    PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
    COG0138
    Location:6590
    PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
    cd01421
    Location:6192
    IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    5485853..5503665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)