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F2r coagulation factor II (thrombin) receptor [ Mus musculus (house mouse) ]

Gene ID: 14062, updated on 30-Apr-2019

Summary

Official Symbol
F2rprovided by MGI
Official Full Name
coagulation factor II (thrombin) receptorprovided by MGI
Primary source
MGI:MGI:101802
See related
Ensembl:ENSMUSG00000048376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cf2r; Par1; ThrR; AI482343
Expression
Broad expression in lung adult (RPKM 53.2), adrenal adult (RPKM 42.2) and 24 other tissues See more
Orthologs

Genomic context

See F2r in Genome Data Viewer
Location:
13 D1; 13 50.21 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (95601789..95618433, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (96371744..96388388, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene coagulation factor II (thrombin) receptor-like 1 Neighboring gene predicted gene, 32640 Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 33074 Neighboring gene coagulation factor II (thrombin) receptor-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC28086

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
G-protein beta-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
heterotrimeric G-protein binding TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
thrombin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thrombin-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
 
connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
 
establishment of synaptic specificity at neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of renin secretion into blood stream IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
platelet activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
thrombin-activated receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
caveola ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
platelet dense tubular network ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteinase-activated receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010169.4NP_034299.2  proteinase-activated receptor 1 precursor

    See identical proteins and their annotated locations for NP_034299.2

    Status: VALIDATED

    Source sequence(s)
    AC159263, AC164547
    Consensus CDS
    CCDS26701.1
    UniProtKB/Swiss-Prot
    P30558
    Related
    ENSMUSP00000061754.5, ENSMUST00000059193.6
    Conserved Domains (1) summary
    pfam00001
    Location:125376
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    95601789..95618433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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