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tfap2a transcription factor AP-2 alpha [ Danio rerio (zebrafish) ]

Gene ID: 140618, updated on 9-May-2021

Summary

Official Symbol
tfap2aprovided by ZNC
Official Full Name
transcription factor AP-2 alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011212-6
See related
Ensembl:ENSDARG00000059279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
a; l; mo; ap2; ap2a; cb93; lock; fb83f04; fc31a07; wu:fb83f04; wu:fc31a07
Orthologs
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Genomic context

See tfap2a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (8721676..8732517, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (8581298..8592139, complement)
103 previous assembly Zv9 (GCF_000002035.4) 24 NC_007135.5 (8521273..8532115, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 epsilon 1 Neighboring gene solute carrier family 35 member B3 Neighboring gene transmembrane protein 14Ca Neighboring gene male germ cell-associated kinase Neighboring gene glial cells missing transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ectodermal placode development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ectodermal placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within iridophore differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within melanocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within_positive_effect melanocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural crest cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural crest cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory placode development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otic placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otic vesicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor AP-2-alpha
Names
lockjaw
low
mob
mont blanc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319158.1NP_001306087.1  transcription factor AP-2-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of alternate start codon, compared to isoform 1. The encoded isoform (2) is shorter and has a disntinct N-terminus, compared to isoform 1.
    Source sequence(s)
    LO018134, LO018137
    UniProtKB/TrEMBL
    F1QUT4
    Related
    ENSDARP00000076787.3, ENSDART00000082351.5
    Conserved Domains (1) summary
    pfam03299
    Location:209409
    TF_AP-2; Transcription factor AP-2
  2. NM_001319159.2NP_001306088.1  transcription factor AP-2-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    LO018134, LO018137
    UniProtKB/TrEMBL
    Q6NYI3
    Related
    ENSDARP00000148170.1, ENSDART00000183624.1
    Conserved Domains (1) summary
    pfam03299
    Location:197397
    TF_AP-2; Transcription factor AP-2
  3. NM_176859.4NP_789829.2  transcription factor AP-2-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    EH587281, EH590405, LO018134, LO018137
    Related
    ENSDARP00000157668.1, ENSDART00000186660.1
    Conserved Domains (1) summary
    pfam03299
    Location:222422
    TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    8721676..8732517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162558.4XP_005162615.1  transcription factor AP-2-alpha isoform X1

    Conserved Domains (1) summary
    pfam03299
    Location:229429
    TF_AP-2; Transcription factor AP-2
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