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ZFP28 ZFP28 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 140612, updated on 23-Nov-2021

Summary

Official Symbol
ZFP28provided by HGNC
Official Full Name
ZFP28 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:17801
See related
Ensembl:ENSG00000196867 MIM:616798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mkr5
Expression
Ubiquitous expression in ovary (RPKM 2.5), brain (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See ZFP28 in Genome Data Viewer
Location:
19q13.43
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56536790..56559192)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57050317..57068177)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene zinc finger protein 471 Neighboring gene ZFP28 divergent transcript Neighboring gene ZNF470 divergent transcript Neighboring gene zinc finger protein 470 Neighboring gene sialic acid binding Ig like lectin 31, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1431, MGC104540, DKFZp686K03205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 28 homolog
Names
krueppel-like zinc finger factor X6
zfp-28
zinc finger factor X6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308440.2NP_001295369.1  zinc finger protein 28 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005498, AF507045, BC028416
    Consensus CDS
    CCDS77363.1
    UniProtKB/Swiss-Prot
    Q8NHY6
    Related
    ENSP00000468603.1, ENST00000591844.5
    Conserved Domains (2) summary
    smart00349
    Location:103163
    KRAB; krueppel associated box
    pfam01352
    Location:103142
    KRAB; KRAB box
  2. NM_020828.2NP_065879.1  zinc finger protein 28 homolog isoform 1

    See identical proteins and their annotated locations for NP_065879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005498, AF507045
    Consensus CDS
    CCDS12946.1
    UniProtKB/Swiss-Prot
    Q8NHY6
    Related
    ENSP00000301318.3, ENST00000301318.8
    Conserved Domains (6) summary
    smart00349
    Location:103163
    KRAB; krueppel associated box
    COG5048
    Location:417806
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:619639
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:420442
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:103142
    KRAB; KRAB box
    pfam13465
    Location:659684
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    56536790..56559192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526463.3XP_011524765.2  zinc finger protein 28 homolog isoform X1

  2. XM_011526462.3XP_011524764.1  zinc finger protein 28 homolog isoform X2

    See identical proteins and their annotated locations for XP_011524764.1

    Conserved Domains (6) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:320709
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:323345
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:562587
    zf-H2C2_2; Zinc-finger double domain
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