Format

Send to:

Choose Destination

Bmpr2 bone morphogenetic protein receptor type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140590, updated on 2-Oct-2018

Summary

Official Symbol
Bmpr2provided by RGD
Official Full Name
bone morphogenetic protein receptor type 2provided by RGD
Primary source
RGD:71082
See related
Ensembl:ENSRNOG00000022196
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bmpr-II
Summary
human homolog is a receptor for bone morpogenetic proteins and plays a role in bone development [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues See more
Orthologs

Genomic context

See Bmpr2 in Genome Data Viewer
Location:
9q31
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66568074..66683019)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (66371542..66486121)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene similar to SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Liver regeneration-related protein LRRGR00002) Neighboring gene NOP58 ribonucleoprotein Neighboring gene pseudogene for diazepam binding inhibitor 1 Neighboring gene family with sequence similarity 117, member B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
BMP binding IEA
Inferred from Electronic Annotation
more info
 
BMP binding ISO
Inferred from Sequence Orthology
more info
 
BMP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor activity, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
artery development ISO
Inferred from Sequence Orthology
more info
 
atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
NOT cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
chondrocyte development IEA
Inferred from Electronic Annotation
more info
 
chondrocyte development ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
endochondral bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
limb development ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
lymphangiogenesis IEA
Inferred from Electronic Annotation
more info
 
lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
lymphatic endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
maternal placenta development ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
mitral valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mitral valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation involved in heart valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation involved in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of lung blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of lung blood pressure ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
retina vasculature development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
semi-lunar valve development IEA
Inferred from Electronic Annotation
more info
 
semi-lunar valve development ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tricuspid valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
tricuspid valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel development IEA
Inferred from Electronic Annotation
more info
 
venous blood vessel development ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-2
Names
bone morphogenetic protein receptor type II
bone morphogenetic protein receptor, type II (serine/threonine kinase)
bone morphogenic protein receptor, type II (serine/threonine kinase)
NP_536332.1
XP_006245013.1
XP_006245014.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080407.1NP_536332.1  bone morphogenetic protein receptor type-2 precursor

    See identical proteins and their annotated locations for NP_536332.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    F1LQC5
    Related
    ENSRNOP00000037011.4, ENSRNOT00000035238.4
    Conserved Domains (3) summary
    smart00220
    Location:204495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:207504
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:60131
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    66568074..66683019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244951.3XP_006245013.1  bone morphogenetic protein receptor type-2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain
  2. XM_006244952.3XP_006245014.1  bone morphogenetic protein receptor type-2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    58627253..58735336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center