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Bmpr2 bone morphogenetic protein receptor type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140590, updated on 22-Dec-2020

Summary

Official Symbol
Bmpr2provided by RGD
Official Full Name
bone morphogenetic protein receptor type 2provided by RGD
Primary source
RGD:71082
See related
Ensembl:ENSRNOG00000022196
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bmpr-II
Summary
human homolog is a receptor for bone morpogenetic proteins and plays a role in bone development [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues See more
Orthologs
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Genomic context

See Bmpr2 in Genome Data Viewer
Location:
9q31
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66568074..66683019)
106 current Rn_Celera (GCF_000002265.2) 9 AC_000077.1 (58627253..58735336)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (66371542..66486121)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene similar to SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Liver regeneration-related protein LRRGR00002) Neighboring gene NOP58 ribonucleoprotein Neighboring gene pseudogene for diazepam binding inhibitor 1 Neighboring gene family with sequence similarity 117, member B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
BMP binding ISO
Inferred from Sequence Orthology
more info
 
BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
aortic valve development ISO
Inferred from Sequence Orthology
more info
 
artery development ISO
Inferred from Sequence Orthology
more info
 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
NOT cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
chondrocyte development ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
endochondral bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
limb development ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
maternal placenta development ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
mitral valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation involved in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
pulmonary valve development ISO
Inferred from Sequence Orthology
more info
 
regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of lung blood pressure ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
semi-lunar valve development ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tricuspid valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel development ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
adherens junction ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-2
Names
bone morphogenetic protein receptor type II
bone morphogenetic protein receptor, type II (serine/threonine kinase)
bone morphogenic protein receptor, type II (serine/threonine kinase)
NP_536332.1
XP_006245013.1
XP_006245014.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080407.1NP_536332.1  bone morphogenetic protein receptor type-2 precursor

    See identical proteins and their annotated locations for NP_536332.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    F1LQC5
    Related
    ENSRNOP00000037011.4, ENSRNOT00000035238.4
    Conserved Domains (3) summary
    smart00220
    Location:204495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:207504
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:60131
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    66568074..66683019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244951.3XP_006245013.1  bone morphogenetic protein receptor type-2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain
  2. XM_006244952.3XP_006245014.1  bone morphogenetic protein receptor type-2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    58627253..58735336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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