Bmpr2 bone morphogenetic protein receptor type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmpr2provided by RGD
Official Full Name: bone morphogenetic protein receptor type 2provided by RGD
Primary source: RGD:71082
See related: Ensembl:ENSRNOG00000022196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bmpr-II
Summary: human homolog is a receptor for bone morpogenetic proteins and plays a role in bone development [RGD, Feb 2006]
Expression: Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (66568074..66683019)
106	current	Rn_Celera (GCF_000002265.2)	9	AC_000077.1 (58627253..58735336)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	9	NC_005108.3 (66371542..66486121)

Chromosome 9 - NC_005108.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMPR2 mutation in cardiomyocytes alters glucose-supported mitochondrial respiration and impairs cellular responses to insulin, including glucose and lipid uptake.
Title: <i>BMPR2</i> dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.
HMGB1/TLR4 signaling promotes hypoxia-induced pulmonary hypertension via suppressing BMPR2 signaling.
Title: HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
During chondrogenic differentiation, the level of miR-143-3p was decreased. Moreover, miR-143-3p could regulate the differentiation process by targeting BMPR2 in bone marrow stem cells.
Title: MiR-143-3p regulates early cartilage differentiation of BMSCs and promotes cartilage damage repair through targeting BMPR2.
Bmpr2 mutant rats develop pulmonary and cardiac characteristics of pulmonary arterial hypertension.
Title: Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.
miR-216a functions as a negative modulator of BMPR2 translation, and is involved in HIV protein(s) and cocaine-mediated enhanced proliferation of pulmonary smooth muscle cells.
Title: Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling.
BMPRII is the key component linking primary cilium and BMP-Smad1/5/8 pathway.
Title: Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium.
Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Title: Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
the findings of these in vitro studies in rat Mesenchymal stem cells support a role for miR-99a as a negative regulator of early chondrogenic differentiation by directly targeting the BMPR2 gene at an early stage.
Title: MicroRNA-99a regulates early chondrogenic differentiation of rat mesenchymal stem cells by targeting the BMPR2 gene.
FGFR-1 inhibition with PD173074 ameliorated pulmonary arterial hypertension and vascular remodeling, and rescued BMPR-II expression.
Title: Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression.
BMP9 is identified as the preferred ligand for preventing apoptosis and enhancing monolayer integrity in endothelial cells from subjects with pulmonary arterial hypertension who bear mutations in the gene encoding BMPR2.
Title: Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

Bmpr2 (e-PCR), detects polymorphism
- UniSTS:496649

RH141266 (e-PCR)
- UniSTS:223262

BF403103 (e-PCR)
- UniSTS:246305

RH134140 (e-PCR)
- UniSTS:217422

AI009781 (e-PCR)
- UniSTS:249950

AW536011 (e-PCR)
- UniSTS:247985

Homology

Homologs of the Bmpr2 gene: The Bmpr2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 296 organisms have orthologs with human gene Bmpr2
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
BMP binding	ISO Inferred from Sequence Orthology more info
BMP receptor activity	ISO Inferred from Sequence Orthology more info
cadherin binding	ISO Inferred from Sequence Orthology more info
growth factor binding	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
transforming growth factor beta-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
BMP signaling pathway	ISO Inferred from Sequence Orthology more info
anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
aortic valve development	ISO Inferred from Sequence Orthology more info
artery development	ISO Inferred from Sequence Orthology more info
atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
NOT atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
blood vessel development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
blood vessel remodeling	ISO Inferred from Sequence Orthology more info
brain development	IEP Inferred from Expression Pattern more info	PubMed
NOT cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to starvation	ISO Inferred from Sequence Orthology more info
chondrocyte development	ISO Inferred from Sequence Orthology more info
endocardial cushion development	ISO Inferred from Sequence Orthology more info
endochondral bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
limb development	ISO Inferred from Sequence Orthology more info
lung alveolus development	ISO Inferred from Sequence Orthology more info
lymphangiogenesis	ISO Inferred from Sequence Orthology more info
lymphatic endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
maternal placenta development	ISO Inferred from Sequence Orthology more info
mesoderm formation	ISO Inferred from Sequence Orthology more info
mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation involved in heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
NOT outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
NOT pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
positive regulation of cartilage development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of ossification	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
pulmonary valve development	ISO Inferred from Sequence Orthology more info
regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
regulation of lung blood pressure	ISO Inferred from Sequence Orthology more info
retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
semi-lunar valve development	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
venous blood vessel development	ISO Inferred from Sequence Orthology more info
ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
adherens junction	ISO Inferred from Sequence Orthology more info
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
caveola	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with caveola	ISO Inferred from Sequence Orthology more info
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
dendrite	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	ISO Inferred from Sequence Orthology more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IEA Inferred from Electronic Annotation more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic density	ISO Inferred from Sequence Orthology more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein receptor type-2

Names: bone morphogenetic protein receptor type II; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)

NP_536332.1

EC 2.7.11.30

XP_006245013.1

EC 2.7.11.30

XP_006245014.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080407.1 → NP_536332.1 bone morphogenetic protein receptor type-2 precursor

See identical proteins and their annotated locations for NP_536332.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

F1LQC5

Related

ENSRNOP00000037011.4, ENSRNOT00000035238.4

Conserved Domains (3) summary

smart00220
Location:204 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:207 → 504

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:60 → 131

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

NC_005108.4 Reference Rnor_6.0 Primary Assembly

Range

66568074..66683019

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244951.3 → XP_006245013.1 bone morphogenetic protein receptor type-2 isoform X1

Conserved Domains (3) summary

smart00220
Location:218 → 509

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:221 → 518

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:74 → 145

Activin_recp; Activin types I and II receptor domain
XM_006244952.3 → XP_006245014.1 bone morphogenetic protein receptor type-2 isoform X2

Conserved Domains (3) summary

smart00220
Location:218 → 509

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:221 → 518

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:74 → 145

Activin_recp; Activin types I and II receptor domain