Bmpr2 bone morphogenetic protein receptor type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmpr2provided by RGD
Official Full Name: bone morphogenetic protein receptor type 2provided by RGD
Primary source: RGD:71082
See related: Ensembl:ENSRNOG00000022196 AllianceGenome:RGD:71082
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bmpr-II
Summary: Enables growth factor binding activity. Involved in brain development and retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (61192718..61307280)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (66568074..66683019)

Chromosome 9 - NC_051344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.
Title: Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.
Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor beta-induced profibrotic responses in lung fibroblasts.
Title: Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts.
The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient.
Title: The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient.
BMPR2 mutation in cardiomyocytes alters glucose-supported mitochondrial respiration and impairs cellular responses to insulin, including glucose and lipid uptake.
Title: BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.
HMGB1/TLR4 signaling promotes hypoxia-induced pulmonary hypertension via suppressing BMPR2 signaling.
Title: HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
During chondrogenic differentiation, the level of miR-143-3p was decreased. Moreover, miR-143-3p could regulate the differentiation process by targeting BMPR2 in bone marrow stem cells.
Title: MiR-143-3p regulates early cartilage differentiation of BMSCs and promotes cartilage damage repair through targeting BMPR2.
Bmpr2 mutant rats develop pulmonary and cardiac characteristics of pulmonary arterial hypertension.
Title: Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.
miR-216a functions as a negative modulator of BMPR2 translation, and is involved in HIV protein(s) and cocaine-mediated enhanced proliferation of pulmonary smooth muscle cells.
Title: Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling.
BMPRII is the key component linking primary cilium and BMP-Smad1/5/8 pathway.
Title: Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium.
Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Title: Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Markers

Bmpr2 (e-PCR), detects polymorphism
- UniSTS:496649

RH141266 (e-PCR)
- UniSTS:223262

BF403103 (e-PCR)
- UniSTS:246305

RH134140 (e-PCR)
- UniSTS:217422

AI009781 (e-PCR)
- UniSTS:249950

AW536011 (e-PCR)
- UniSTS:247985

Homology

Homologs of the Bmpr2 gene: The Bmpr2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 371 organisms have orthologs with human gene Bmpr2
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activator activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in aortic valve development	ISO Inferred from Sequence Orthology more info
involved_in artery development	ISO Inferred from Sequence Orthology more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
involved_in endochondral bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lymphangiogenesis	ISO Inferred from Sequence Orthology more info
involved_in lymphatic endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell proliferation involved in heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pulmonary valve development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of lung blood pressure	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in semi-lunar valve development	ISO Inferred from Sequence Orthology more info
involved_in transmembrane receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in venous blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with caveola	ISO Inferred from Sequence Orthology more info
is_active_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in integral component of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein receptor type-2

Names: bone morphogenetic protein receptor type II; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)

NP_536332.1

EC 2.7.11.30

XP_006245013.1

EC 2.7.11.30

XP_006245014.1

EC 2.7.11.30

XP_038938898.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080407.1 → NP_536332.1 bone morphogenetic protein receptor type-2 precursor

See identical proteins and their annotated locations for NP_536332.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

F1LQC5

Related

ENSRNOP00000037011.5, ENSRNOT00000035238.5

Conserved Domains (3) summary

smart00220
Location:204 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:207 → 504

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:60 → 131

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051344.1 Reference mRatBN7.2 Primary Assembly

Range

61192718..61307280

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244951.4 → XP_006245013.1 bone morphogenetic protein receptor type-2 isoform X1

Related

ENSRNOP00000095162.1, ENSRNOT00000100349.1

Conserved Domains (3) summary

smart00220
Location:218 → 509

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:221 → 518

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:74 → 145

Activin_recp; Activin types I and II receptor domain
XM_006244952.4 → XP_006245014.1 bone morphogenetic protein receptor type-2 isoform X2

Conserved Domains (3) summary

smart00220
Location:218 → 509

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14054
Location:221 → 518

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors

pfam01064
Location:74 → 145

Activin_recp; Activin types I and II receptor domain
XM_039082970.1 → XP_038938898.1 bone morphogenetic protein receptor type-2 isoform X3

Conserved Domains (1) summary

cd14054
Location:34 → 331

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors