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Bmpr2 bone morphogenetic protein receptor type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140590, updated on 18-Jul-2022

Summary

Official Symbol
Bmpr2provided by RGD
Official Full Name
bone morphogenetic protein receptor type 2provided by RGD
Primary source
RGD:71082
See related
Ensembl:ENSRNOG00000022196 AllianceGenome:RGD:71082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bmpr-II
Summary
Enables growth factor binding activity. Involved in brain development and retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues See more
Orthologs
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Genomic context

See Bmpr2 in Genome Data Viewer
Location:
9q31
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61192718..61307280)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66568074..66683019)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD11B Neighboring gene small nucleolar RNA SNORD11 Neighboring gene NOP58 ribonucleoprotein Neighboring gene pseudogene for diazepam binding inhibitor 1 Neighboring gene family with sequence similarity 117, member B Neighboring gene uncharacterized LOC120094801

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables BMP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in aortic valve development ISO
Inferred from Sequence Orthology
more info
 
involved_in artery development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
NOT involved_in cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
involved_in endochondral bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within maternal placenta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal arch artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pulmonary valve development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lung blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in semi-lunar valve development ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tricuspid valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in venous blood vessel development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bone morphogenetic protein receptor type-2
Names
bone morphogenetic protein receptor type II
bone morphogenetic protein receptor, type II (serine/threonine kinase)
bone morphogenic protein receptor, type II (serine/threonine kinase)
NP_536332.1
XP_006245013.1
XP_006245014.1
XP_038938898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080407.1NP_536332.1  bone morphogenetic protein receptor type-2 precursor

    See identical proteins and their annotated locations for NP_536332.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    F1LQC5
    Related
    ENSRNOP00000037011.5, ENSRNOT00000035238.5
    Conserved Domains (3) summary
    smart00220
    Location:204495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:207504
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:60131
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    61192718..61307280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244951.4XP_006245013.1  bone morphogenetic protein receptor type-2 isoform X1

    Related
    ENSRNOP00000095162.1, ENSRNOT00000100349.1
    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain
  2. XM_006244952.4XP_006245014.1  bone morphogenetic protein receptor type-2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:218509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14054
    Location:221518
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
    pfam01064
    Location:74145
    Activin_recp; Activin types I and II receptor domain
  3. XM_039082970.1XP_038938898.1  bone morphogenetic protein receptor type-2 isoform X3

    Conserved Domains (1) summary
    cd14054
    Location:34331
    STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors