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Ryk receptor-like tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 140585, updated on 2-Oct-2018

Summary

Official Symbol
Rykprovided by RGD
Official Full Name
receptor-like tyrosine kinaseprovided by RGD
Primary source
RGD:620549
See related
Ensembl:ENSRNOG00000008593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
an orphan receptor [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 343.6), Heart (RPKM 314.0) and 9 other tissues See more
Orthologs

Genomic context

See Ryk in Genome Data Viewer
Location:
8q32
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111326339..111398640)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (110718666..110790096)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549628 Neighboring gene angiomotin like 2 Neighboring gene uncharacterized LOC102549824 Neighboring gene solute carrier organic anion transporter family, member 2a1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
frizzled binding IEA
Inferred from Electronic Annotation
more info
 
frizzled binding ISO
Inferred from Sequence Orthology
more info
 
NOT protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
axon guidance ISO
Inferred from Sequence Orthology
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemorepulsion of dopaminergic neuron axon IEA
Inferred from Electronic Annotation
more info
 
chemorepulsion of dopaminergic neuron axon ISO
Inferred from Sequence Orthology
more info
 
commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development ISO
Inferred from Sequence Orthology
more info
 
midbrain dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
NOT protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase RYK
NP_536327.1
XP_008764695.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080402.1NP_536327.1  tyrosine-protein kinase RYK precursor

    See identical proteins and their annotated locations for NP_536327.1

    Status: PROVISIONAL

    Source sequence(s)
    AY669340
    UniProtKB/TrEMBL
    Q6BC88
    Related
    ENSRNOP00000063141.3, ENSRNOT00000067203.3
    Conserved Domains (3) summary
    smart00469
    Location:47180
    WIF; Wnt-inhibitory factor-1 like domain
    cd05043
    Location:310590
    PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
    pfam07714
    Location:317583
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    111326339..111398640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766473.2XP_008764695.1  tyrosine-protein kinase RYK isoform X1

    Conserved Domains (3) summary
    smart00469
    Location:47180
    WIF; Wnt-inhibitory factor-1 like domain
    cd05043
    Location:307587
    PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
    pfam07714
    Location:314580
    Pkinase_Tyr; Protein tyrosine kinase

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    102827084..102871070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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