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Elmo1 engulfment and cell motility 1 [ Mus musculus (house mouse) ]

Gene ID: 140580, updated on 13-Dec-2022

Summary

Official Symbol
Elmo1provided by MGI
Official Full Name
engulfment and cell motility 1provided by MGI
Primary source
MGI:MGI:2153044
See related
Ensembl:ENSMUSG00000041112 AllianceGenome:MGI:2153044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CED-12; 6330578D22Rik; C230095H21Rik
Summary
Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within actin filament-based process and phagocytosis. Part of guanyl-nucleotide exchange factor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and vibrissa. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 18.2), thymus adult (RPKM 13.4) and 27 other tissues See more
Orthologs
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Genomic context

See Elmo1 in Genome Data Viewer
Location:
13; 13 A2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (20274677..20792523)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (20090507..20608353)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 141 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene predicted gene 5446 Neighboring gene predicted gene, 32036 Neighboring gene predicted gene 7614 Neighboring gene acyloxyacyl hydrolase Neighboring gene predicted gene, 32242

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0281

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Rac protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament-based process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
engulfment and cell motility protein 1
Names
engulfment and cell motility 1, ced-12 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080288.2NP_525027.1  engulfment and cell motility protein 1 isoform 3

    See identical proteins and their annotated locations for NP_525027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
    Source sequence(s)
    AC124183, AC124751, AC126555, AC132085, AC153143, AC165346
    Consensus CDS
    CCDS26265.1
    UniProtKB/Swiss-Prot
    Q8BPU7, Q91ZU3
    UniProtKB/TrEMBL
    A0A6P5QX00, A0A8C6HH55
    Related
    ENSMUSP00000072334.5, ENSMUST00000072519.7
    Conserved Domains (3) summary
    cd13359
    Location:546675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116279
    DUF3361; Domain of unknown function (DUF3361)
  2. NM_198093.3NP_932761.1  engulfment and cell motility protein 1 isoform 2

    See identical proteins and their annotated locations for NP_932761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AK049051, BB647467, BC024727, BE943952
    UniProtKB/Swiss-Prot
    Q8BPU7
    UniProtKB/TrEMBL
    A0A6P7QHB1
    Conserved Domains (1) summary
    cd13359
    Location:66195
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    20274677..20792523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516544.4XP_006516607.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516607.1

    UniProtKB/TrEMBL
    A0A6P7QHA7, A0A8C6HHQ6
    Conserved Domains (3) summary
    cd13359
    Location:561690
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:318496
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116294
    DUF3361; Domain of unknown function (DUF3361)
  2. XM_006516547.3XP_006516610.1  engulfment and cell motility protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006516610.1

    UniProtKB/Swiss-Prot
    Q8BPU7, Q91ZU3
    UniProtKB/TrEMBL
    A0A6P5QX00, A0A8C6HH55
    Conserved Domains (3) summary
    cd13359
    Location:546675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116279
    DUF3361; Domain of unknown function (DUF3361)
  3. XM_006516546.3XP_006516609.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516609.1

    UniProtKB/TrEMBL
    A0A6P7QHA7, A0A8C6HHQ6
    Conserved Domains (3) summary
    cd13359
    Location:561690
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:318496
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116294
    DUF3361; Domain of unknown function (DUF3361)
  4. XM_006516545.5XP_006516608.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006516608.1

    UniProtKB/TrEMBL
    A0A6P7QHA7, A0A8C6HHQ6
    Conserved Domains (3) summary
    cd13359
    Location:561690
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:318496
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116294
    DUF3361; Domain of unknown function (DUF3361)
  5. XM_030247141.2XP_030103001.1  engulfment and cell motility protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q91ZU3
    UniProtKB/TrEMBL
    A0A6P5QX00, A0A8C6HH55
    Conserved Domains (3) summary
    cd13359
    Location:546675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116279
    DUF3361; Domain of unknown function (DUF3361)
  6. XM_030247142.1XP_030103002.1  engulfment and cell motility protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A6P7Q832
    Conserved Domains (3) summary
    cd13359
    Location:465594
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:222400
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:20198
    DUF3361; Domain of unknown function (DUF3361)