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Elmo2 engulfment and cell motility 2 [ Mus musculus (house mouse) ]

Gene ID: 140579, updated on 27-Jan-2018

Summary

Official Symbol
Elmo2provided by MGI
Official Full Name
engulfment and cell motility 2provided by MGI
Primary source
MGI:MGI:2153045
See related
Ensembl:ENSMUSG00000017670 Vega:OTTMUSG00000001171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CED-12; 1190002F24Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 32.9), frontal lobe adult (RPKM 28.9) and 28 other tissues See more
Orthologs

Genomic context

See Elmo2 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (165288031..165326479, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (165113531..165151979, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cadherin 22 Neighboring gene predicted gene, 36748 Neighboring gene solute carrier family 35, member C2 Neighboring gene zinc finger protein 663 Neighboring gene predicted gene, 29831 Neighboring gene zinc finger protein 334

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • mKIAA1834

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
engulfment and cell motility protein 2
Names
CED-12 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302752.1NP_001289681.1  engulfment and cell motility protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001289681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK035710, AK038455, AW049501
    Consensus CDS
    CCDS17075.1
    UniProtKB/Swiss-Prot
    Q8BHL5
    Related
    ENSMUSP00000099380.2, OTTMUSP00000001119, ENSMUST00000103091.8, OTTMUST00000002283
    Conserved Domains (3) summary
    cd13359
    Location:539668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:297469
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115271
    DUF3361; Domain of unknown function (DUF3361)
  2. NM_001302754.1NP_001289683.1  engulfment and cell motility protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001289683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the coding region compared to variant 2. It encodes isoform 4, which is shorter than isoform 2.
    Source sequence(s)
    AK033918, AK035710, AK038455, AW049501
    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:537666
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295467
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115269
    DUF3361; Domain of unknown function (DUF3361)
  3. NM_080287.2NP_525026.2  engulfment and cell motility protein 2 isoform 3

    See identical proteins and their annotated locations for NP_525026.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AI666775, AK035710, AK045428, BC033418
    Consensus CDS
    CCDS17075.1
    UniProtKB/Swiss-Prot
    Q8BHL5
    Related
    ENSMUSP00000091887.4, OTTMUSP00000001122, ENSMUST00000094329.10, OTTMUST00000002288
    Conserved Domains (3) summary
    cd13359
    Location:539668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:297469
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115271
    DUF3361; Domain of unknown function (DUF3361)
  4. NM_207706.1NP_997589.1  engulfment and cell motility protein 2 isoform 2

    See identical proteins and their annotated locations for NP_997589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AI666775, AK032033, AK035710, AK045428
    Consensus CDS
    CCDS17076.1
    UniProtKB/Swiss-Prot
    Q8BHL5
    Related
    ENSMUSP00000073691.6, OTTMUSP00000017935, ENSMUST00000074046.12, OTTMUST00000002287
    Conserved Domains (3) summary
    cd13359
    Location:551680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:309481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115283
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    165288031..165326479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315487.1XP_017170976.1  engulfment and cell motility protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:551680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:309481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115283
    DUF3361; Domain of unknown function (DUF3361)
  2. XM_011239284.1XP_011237586.1  engulfment and cell motility protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237586.1

    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:551680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:309481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115283
    DUF3361; Domain of unknown function (DUF3361)
  3. XM_011239285.1XP_011237587.1  engulfment and cell motility protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237587.1

    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:551680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:309481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115283
    DUF3361; Domain of unknown function (DUF3361)
  4. XM_011239286.2XP_011237588.1  engulfment and cell motility protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011237588.1

    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:539668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:297469
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115271
    DUF3361; Domain of unknown function (DUF3361)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207705.1: Suppressed sequence

    Description
    NM_207705.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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