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Smc1b structural maintenance of chromosomes 1B [ Mus musculus (house mouse) ]

Gene ID: 140557, updated on 12-May-2024

Summary

Official Symbol
Smc1bprovided by MGI
Official Full Name
structural maintenance of chromosomes 1Bprovided by MGI
Primary source
MGI:MGI:2154049
See related
Ensembl:ENSMUSG00000022432 AllianceGenome:MGI:2154049
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMC-1B; Smc1l2; SMC1beta
Summary
Enables DNA binding activity. Acts upstream of or within meiotic cell cycle and sister chromatid cohesion. Located in chromosome, centromeric region and lateral element. Part of nuclear meiotic cohesin complex. Orthologous to human SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 8.5) See more
Orthologs
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Genomic context

See Smc1b in Genome Data Viewer
Location:
15 E2; 15 40.25 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84948890..85016158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85064689..85131957, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene predicted gene, 52194 Neighboring gene uroplakin 3A Neighboring gene family with sequence similarity 118, member A Neighboring gene STARR-seq mESC enhancer starr_39377 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene predicted gene, 19277

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within meiotic cell cycle IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sister chromatid cohesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
structural maintenance of chromosomes protein 1B
Names
SMC protein 1B
SMC-1-beta
structural maintenace of chromosomes 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080470.1NP_536718.1  structural maintenance of chromosomes protein 1B

    See identical proteins and their annotated locations for NP_536718.1

    Status: PROVISIONAL

    Source sequence(s)
    AF303827
    Consensus CDS
    CCDS27718.1
    UniProtKB/Swiss-Prot
    Q920F6
    UniProtKB/TrEMBL
    A1L2Z0
    Related
    ENSMUSP00000023068.7, ENSMUST00000023068.8
    Conserved Domains (4) summary
    cd03275
    Location:4148
    ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
    smart00968
    Location:513628
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:31199
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:421492
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    84948890..85016158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)