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Eri3 exoribonuclease 3 [ Mus musculus (house mouse) ]

Gene ID: 140546, updated on 5-Mar-2024

Summary

Official Symbol
Eri3provided by MGI
Official Full Name
exoribonuclease 3provided by MGI
Primary source
MGI:MGI:2153887
See related
Ensembl:ENSMUSG00000033423 AllianceGenome:MGI:2153887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PINT1; Prnpip1
Summary
Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; major salivary gland; and trigeminal nerve. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 32.0), ovary adult (RPKM 28.1) and 28 other tissues See more
Orthologs
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Genomic context

See Eri3 in Genome Data Viewer
Location:
4 D1; 4 53.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117407416..117531494)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117550241..117674297)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene predicted gene 12827 Neighboring gene predicted gene, 34669 Neighboring gene STARR-positive B cell enhancer mm9_chr4:117222596-117222897 Neighboring gene STARR-seq mESC enhancer starr_11185 Neighboring gene STARR-seq mESC enhancer starr_11187 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117354782-117355011 Neighboring gene DNA methyltransferase 1-associated protein 1 Neighboring gene predicted gene, 34746

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ERI1 exoribonuclease 3
Names
prion interactor 1
prion protein interacting protein 1
prion protein-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285899.2NP_001272828.1  ERI1 exoribonuclease 3 isoform b

    See identical proteins and their annotated locations for NP_001272828.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:105282
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  2. NM_001285901.2NP_001272830.1  ERI1 exoribonuclease 3 isoform c

    See identical proteins and their annotated locations for NP_001272830.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  3. NM_001285902.2NP_001272831.1  ERI1 exoribonuclease 3 isoform d

    See identical proteins and their annotated locations for NP_001272831.1

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/Swiss-Prot
    Q8C460
    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  4. NM_001356404.2NP_001343333.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  5. NM_001356405.1NP_001343334.1  ERI1 exoribonuclease 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (e) has the same N- and C-termini, but is 2 aa shorter than isoform a.
    Source sequence(s)
    AK083017, BE944838, BY255598
    Conserved Domains (1) summary
    cd06133
    Location:144321
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  6. NM_001379279.1NP_001366208.1  ERI1 exoribonuclease 3 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:146345
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  7. NM_001379280.1NP_001366209.1  ERI1 exoribonuclease 3 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:107284
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  8. NM_001379281.1NP_001366210.1  ERI1 exoribonuclease 3 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  9. NM_001379282.1NP_001366211.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  10. NM_001379283.1NP_001366212.1  ERI1 exoribonuclease 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  11. NM_001379284.1NP_001366213.1  ERI1 exoribonuclease 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  12. NM_001379285.1NP_001366214.1  ERI1 exoribonuclease 3 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Conserved Domains (1) summary
    cd06133
    Location:35205
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  13. NM_080469.5NP_536717.2  ERI1 exoribonuclease 3 isoform a

    See identical proteins and their annotated locations for NP_536717.2

    Status: VALIDATED

    Source sequence(s)
    AL645740, AL671520
    Consensus CDS
    CCDS18535.1
    UniProtKB/Swiss-Prot
    A2ADW0, A2ADW2, Q149R0, Q68FL7, Q8C460, Q923K5
    Related
    ENSMUSP00000042796.9, ENSMUST00000037127.15
    Conserved Domains (1) summary
    cd06133
    Location:146323
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117407416..117531494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319962.3XP_017175451.2  ERI1 exoribonuclease 3 isoform X5

    Conserved Domains (1) summary
    cd06133
    Location:121285
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  2. XM_030253198.2XP_030109058.2  ERI1 exoribonuclease 3 isoform X8

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:121298
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  3. XM_036163665.1XP_036019558.1  ERI1 exoribonuclease 3 isoform X10

    Conserved Domains (1) summary
    cd06133
    Location:121256
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  4. XM_030253202.1XP_030109062.1  ERI1 exoribonuclease 3 isoform X12

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68245
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  5. XM_017319971.2XP_017175460.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  6. XM_036163669.1XP_036019562.1  ERI1 exoribonuclease 3 isoform X14

    Conserved Domains (1) summary
    cd06133
    Location:1168
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  7. XM_017319970.3XP_017175459.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  8. XM_017319961.3XP_017175450.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  9. XM_030253200.1XP_030109060.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  10. XM_017319964.3XP_017175453.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  11. XM_036163663.1XP_036019556.1  ERI1 exoribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  12. XM_017319972.3XP_017175461.1  ERI1 exoribonuclease 3 isoform X16

    Conserved Domains (1) summary
    cd06133
    Location:1114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  13. XM_017319965.3XP_017175454.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  14. XM_036163670.1XP_036019563.1  ERI1 exoribonuclease 3 isoform X15

    Conserved Domains (1) summary
    cd06133
    Location:1146
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  15. XM_011240437.4XP_011238739.2  ERI1 exoribonuclease 3 isoform X1

    Conserved Domains (1) summary
    cd06133
    Location:146310
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  16. XM_030253195.2XP_030109055.1  ERI1 exoribonuclease 3 isoform X3

    Conserved Domains (1) summary
    cd06133
    Location:146281
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  17. XM_017319960.3XP_017175449.1  ERI1 exoribonuclease 3 isoform X2

    Conserved Domains (1) summary
    cd06133
    Location:144308
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  18. XM_036163661.1XP_036019554.1  ERI1 exoribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    Q8VC93
    Conserved Domains (1) summary
    cd06133
    Location:68267
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  19. XM_036163664.1XP_036019557.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  20. XM_036163671.1XP_036019564.1  ERI1 exoribonuclease 3 isoform X16

    Related
    ENSMUST00000146384.8
    Conserved Domains (1) summary
    cd06133
    Location:1114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  21. XM_036163667.1XP_036019560.1  ERI1 exoribonuclease 3 isoform X13

    Conserved Domains (1) summary
    cd06133
    Location:1133
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  22. XM_036163668.1XP_036019561.1  ERI1 exoribonuclease 3 isoform X14

    Conserved Domains (1) summary
    cd06133
    Location:1168
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  23. XM_030253209.1XP_030109069.1  ERI1 exoribonuclease 3 isoform X16

    Conserved Domains (1) summary
    cd06133
    Location:1114
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  24. XM_036163666.1XP_036019559.1  ERI1 exoribonuclease 3 isoform X11

    Conserved Domains (1) summary
    cd06133
    Location:35192
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  25. XM_017319966.3XP_017175455.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  26. XM_030253208.1XP_030109068.1  ERI1 exoribonuclease 3 isoform X9

    Conserved Domains (1) summary
    cd06133
    Location:68203
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  27. XM_036163662.1XP_036019555.1  ERI1 exoribonuclease 3 isoform X7

    Conserved Domains (1) summary
    cd06133
    Location:105269
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  28. XM_017319967.2XP_017175456.1  ERI1 exoribonuclease 3 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:68232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

RNA

  1. XR_003954874.2 RNA Sequence

  2. XR_004941810.1 RNA Sequence

  3. XR_003954875.2 RNA Sequence

  4. XR_003954876.2 RNA Sequence