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RNF32 ring finger protein 32 [ Homo sapiens (human) ]

Gene ID: 140545, updated on 23-Nov-2021

Summary

Official Symbol
RNF32provided by HGNC
Official Full Name
ring finger protein 32provided by HGNC
Primary source
HGNC:HGNC:17118
See related
Ensembl:ENSG00000105982 MIM:610241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD15; LMBR2; FKSG33
Summary
The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in testis (RPKM 12.4), bone marrow (RPKM 0.9) and 4 other tissues See more
Orthologs
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Genomic context

See RNF32 in Genome Data Viewer
Location:
7q36.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (156640202..156678333)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (156433468..156469824)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNF32 divergent transcript Neighboring gene long intergenic non-protein coding RNA 244 Neighboring gene ribosomal protein L26 pseudogene 23 Neighboring gene RNF32 antisense RNA 1 Neighboring gene limb development membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 13578 Neighboring gene ZRS shadow enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184996.2NP_001171925.1  RING finger protein 32 isoform a

    See identical proteins and their annotated locations for NP_001171925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AK314067, AL136874
    Consensus CDS
    CCDS5944.1
    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Related
    ENSP00000405588.2, ENST00000432459.6
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  2. NM_001184997.1NP_001171926.1  RING finger protein 32 isoform a

    See identical proteins and their annotated locations for NP_001171926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AA412402, AF325690, AF441222
    Consensus CDS
    CCDS5944.1
    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Related
    ENSP00000376499.2, ENST00000392743.6
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  3. NM_001308273.2NP_001295202.1  RING finger protein 32 isoform b

    See identical proteins and their annotated locations for NP_001295202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL136874, BC028120, DB198291
    Consensus CDS
    CCDS78293.1
    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    G5E940
    Related
    ENSP00000308894.8, ENST00000311822.12
    Conserved Domains (2) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
  4. NM_001308274.1NP_001295203.1  RING finger protein 32 isoform c

    See identical proteins and their annotated locations for NP_001295203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains alternate 3' exon structure, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BC015416
    Consensus CDS
    CCDS78292.1
    UniProtKB/Swiss-Prot
    Q9H0A6
    Related
    ENSP00000376497.2, ENST00000392741.6
    Conserved Domains (2) summary
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    cd16677
    Location:126169
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
  5. NM_030936.4NP_112198.1  RING finger protein 32 isoform a

    See identical proteins and their annotated locations for NP_112198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AL136874, BI460257, DB445126
    Consensus CDS
    CCDS5944.1
    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Related
    ENSP00000315950.5, ENST00000317955.10
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain

RNA

  1. NR_131778.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF441224, AL136874
    Related
    ENST00000392747.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    156640202..156678333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446666.1XP_024302434.1  RING finger protein 32 isoform X5

    Related
    ENSP00000385815.2, ENST00000404282.6
    Conserved Domains (2) summary
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    cd16677
    Location:126169
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
  2. XM_011515811.3XP_011514113.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514113.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  3. XM_017011753.1XP_016867242.1  RING finger protein 32 isoform X2

  4. XM_017011754.1XP_016867243.1  RING finger protein 32 isoform X4

    UniProtKB/TrEMBL
    G5E940
    Conserved Domains (2) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
  5. XM_017011755.1XP_016867244.1  RING finger protein 32 isoform X5

    UniProtKB/Swiss-Prot
    Q9H0A6
    Conserved Domains (2) summary
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    cd16677
    Location:126169
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
  6. XM_011515813.2XP_011514115.1  RING finger protein 32 isoform X3

    Conserved Domains (2) summary
    pfam00612
    Location:175194
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:278339
    zf-RING_2; Ring finger domain
  7. XM_011515810.3XP_011514112.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514112.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  8. XM_011515806.3XP_011514108.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514108.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  9. XM_011515804.3XP_011514106.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514106.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  10. XM_011515812.3XP_011514114.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514114.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  11. XM_011515805.3XP_011514107.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514107.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Related
    ENSP00000385285.1, ENST00000405335.5
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  12. XM_011515809.3XP_011514111.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514111.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  13. XM_011515808.3XP_011514110.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514110.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  14. XM_005249522.5XP_005249579.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_005249579.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain
  15. XM_011515807.3XP_011514109.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011514109.1

    UniProtKB/Swiss-Prot
    Q9H0A6
    UniProtKB/TrEMBL
    A0A024RD87
    Conserved Domains (3) summary
    cd00162
    Location:127171
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00612
    Location:188207
    IQ; IQ calmodulin-binding motif
    pfam13639
    Location:291352
    zf-RING_2; Ring finger domain

RNA

  1. XR_927367.3 RNA Sequence

  2. XR_428168.3 RNA Sequence

  3. XR_001744552.1 RNA Sequence

  4. XR_927369.2 RNA Sequence

  5. XR_001744553.1 RNA Sequence

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