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Eya3 EYA transcriptional coactivator and phosphatase 3 [ Mus musculus (house mouse) ]

Gene ID: 14050, updated on 8-Feb-2024

Summary

Official Symbol
Eya3provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 3provided by MGI
Primary source
MGI:MGI:109339
See related
Ensembl:ENSMUSG00000028886 AllianceGenome:MGI:109339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; rhombomere; and sensory organ. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.7), limb E14.5 (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Eya3 in Genome Data Viewer
Location:
4 D2.3; 4 65.68 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132366303..132452076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132639025..132724765)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene predicted gene, 54261 Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene platelet-activating factor receptor Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene X-linked Kx blood group related 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables histone H2AXY142 phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
eyes absent homolog 3
Names
eyes absent 3 homolog
NP_001390684.1
NP_001390685.1
NP_001390686.1
NP_001390687.1
NP_001390688.1
NP_001390689.1
NP_034296.2
NP_997592.1
NP_997596.1
XP_006538603.1
XP_036019552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403755.1NP_001390684.1  eyes absent homolog 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627130
  2. NM_001403756.1NP_001390685.1  eyes absent homolog 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627130
  3. NM_001403757.1NP_001390686.1  eyes absent homolog 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627130
  4. NM_001403758.1NP_001390687.1  eyes absent homolog 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627130
  5. NM_001403759.1NP_001390688.1  eyes absent homolog 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627130
  6. NM_001403760.1NP_001390689.1  eyes absent homolog 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL627130
  7. NM_010166.4NP_034296.2  eyes absent homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_034296.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18730.1
    UniProtKB/Swiss-Prot
    G5E8I5, P97480, P97768
    Related
    ENSMUSP00000078157.5, ENSMUST00000079157.11
    Conserved Domains (1) summary
    TIGR01658
    Location:239510
    EYA-cons_domain; eyes absent protein conserved domain
  8. NM_210071.3NP_997592.1  eyes absent homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_997592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18729.1
    UniProtKB/TrEMBL
    Q6P4T3
    Related
    ENSMUSP00000080425.7, ENSMUST00000081726.13
    Conserved Domains (1) summary
    TIGR01658
    Location:255526
    EYA-cons_domain; eyes absent protein conserved domain
  9. NM_211357.3NP_997596.1  eyes absent homolog 3 isoform 3

    See identical proteins and their annotated locations for NP_997596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL627130
    Consensus CDS
    CCDS18731.1
    UniProtKB/TrEMBL
    Q6P4T3
    Related
    ENSMUSP00000020197.8, ENSMUST00000020197.14
    Conserved Domains (1) summary
    TIGR01658
    Location:145416
    EYA-cons_domain; eyes absent protein conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132366303..132452076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538540.5XP_006538603.1  eyes absent homolog 3 isoform X5

    UniProtKB/TrEMBL
    A2A953
    Related
    ENSMUSP00000123045.2, ENSMUST00000135299.8
    Conserved Domains (1) summary
    TIGR01658
    Location:301360
    EYA-cons_domain; eyes absent protein conserved domain
  2. XM_036163659.1XP_036019552.1  eyes absent homolog 3 isoform X3

    Conserved Domains (1) summary
    TIGR01658
    Location:253524
    EYA-cons_domain; eyes absent protein conserved domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_211356.1: Suppressed sequence

    Description
    NM_211356.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.