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Bhlhe23 basic helix-loop-helix family, member e23 [ Mus musculus (house mouse) ]

Gene ID: 140489, updated on 18-Sep-2024

Summary

Official Symbol
Bhlhe23provided by MGI
Official Full Name
basic helix-loop-helix family, member e23provided by MGI
Primary source
MGI:MGI:2153710
See related
Ensembl:ENSMUSG00000045493 AllianceGenome:MGI:2153710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BETA4; Beta3b; Bhlhb4; A930001L02Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within eye morphogenesis; negative regulation of retinal cell programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and urinary system. Orthologous to human BHLHE23 (basic helix-loop-helix family member e23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Bhlhe23 in Genome Data Viewer
Location:
2 H4; 2 103.34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180416174..180418693, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180774381..180776900, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene death inducer-obliterator 1 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene predicted gene 14340 Neighboring gene predicted gene 14342 Neighboring gene predicted gene 14344

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
class E basic helix-loop-helix protein 23
Names
basic helix-loop-helix domain containing, class B4
beta-cell E-box transactivating factor 4
class B basic helix-loop-helix protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080641.5NP_542372.2  class E basic helix-loop-helix protein 23

    See identical proteins and their annotated locations for NP_542372.2

    Status: VALIDATED

    Source sequence(s)
    AK044215, AK051155, BE986685
    Consensus CDS
    CCDS17187.1
    UniProtKB/Swiss-Prot
    Q71MB7, Q8BGW3
    UniProtKB/TrEMBL
    Q0VEJ8
    Related
    ENSMUSP00000104506.2, ENSMUST00000108878.2
    Conserved Domains (1) summary
    smart00353
    Location:104158
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180416174..180418693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)