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Hnmt histamine N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 140483, updated on 5-Jan-2022

Summary

Official Symbol
Hnmtprovided by MGI
Official Full Name
histamine N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:2153181
See related
Ensembl:ENSMUSG00000026986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI788969; 1500031F01Rik
Summary
Enables N-methyltransferase activity. Predicted to be involved in histamine catabolic process and methylation. Predicted to act upstream of or within regulation of neurotransmitter levels. Predicted to be located in several cellular components, including centrosome; neuron projection; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive non-syndromic intellectual disability; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in frontal lobe adult (RPKM 4.2), cortex adult (RPKM 3.6) and 14 other tissues See more
Orthologs
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Genomic context

See Hnmt in Genome Data Viewer
Location:
2; 2 A3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23892923..23939756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24002911..24049758, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (23858431..23904899, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2D 3 pseudogene Neighboring gene speckle-type BTB/POZ protein-like Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene TATA box binding protein like 2 Neighboring gene interleukin 36B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histamine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurotransmitter levels TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histamine N-methyltransferase
Names
HMT
NP_536710.1
XP_006497733.1
XP_006497734.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080462.2NP_536710.1  histamine N-methyltransferase

    See identical proteins and their annotated locations for NP_536710.1

    Status: VALIDATED

    Source sequence(s)
    AF297037, AK160131, AW456742
    Consensus CDS
    CCDS15731.1
    UniProtKB/Swiss-Prot
    Q91VF2
    UniProtKB/TrEMBL
    A2AQK4
    Related
    ENSMUSP00000062747.6, ENSMUST00000051416.12
    Conserved Domains (1) summary
    pfam13489
    Location:32218
    Methyltransf_23; Methyltransferase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    23892923..23939756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497670.4XP_006497733.1  histamine N-methyltransferase isoform X1

    Conserved Domains (1) summary
    pfam13489
    Location:44230
    Methyltransf_23; Methyltransferase domain
  2. XM_006497671.5XP_006497734.1  histamine N-methyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006497734.1

    UniProtKB/Swiss-Prot
    Q91VF2
    UniProtKB/TrEMBL
    A2AQK4
    Related
    ENSMUSP00000110142.2, ENSMUST00000114498.8
    Conserved Domains (1) summary
    pfam13489
    Location:32218
    Methyltransf_23; Methyltransferase domain
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