Format

Send to:

Choose Destination

Eya1 EYA transcriptional coactivator and phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 14048, updated on 23-Jun-2021

Summary

Official Symbol
Eya1provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 1provided by MGI
Primary source
MGI:MGI:109344
See related
Ensembl:ENSMUSG00000025932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b; bor
Expression
Broad expression in CNS E11.5 (RPKM 1.6), limb E14.5 (RPKM 1.5) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eya1 in Genome Data Viewer
Location:
1 A3; 1 4.31 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (14239177..14381259, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (14168953..14311035, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (14159039..14300280, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19122 Neighboring gene predicted gene, 39596 Neighboring gene adaptor-related protein complex 2, beta 1 subunit pseudogene Neighboring gene predicted gene 9947 Neighboring gene musculin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within anatomical structure development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular protein localization IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 
acts_upstream_of_or_within establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
 
involved_in histone dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 
involved_in mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otic vesicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otic vesicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within outer ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eyes absent homolog 1
Names
eyes absent 1 homolog
NP_001239121.1
NP_001297388.1
NP_034294.2
XP_006495509.1
XP_006495514.1
XP_006495515.1
XP_011236646.1
XP_011236648.1
XP_017170837.1
XP_017170870.1
XP_017170903.1
XP_017170911.1
XP_030103330.1
XP_036015537.1
XP_036015555.1
XP_036015560.1
XP_036015568.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252192.1NP_001239121.1  eyes absent homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001239121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region and uses a different start codon compared to variant 3. The resulting isoform (2) contains a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AK042412, BC060260
    Consensus CDS
    CCDS56621.1
    UniProtKB/TrEMBL
    Q6PAJ8, Q8C9D0
    Related
    ENSMUSP00000079493.9, ENSMUST00000080664.14
    Conserved Domains (2) summary
    TIGR01658
    Location:287558
    EYA-cons_domain; eyes absent protein conserved domain
    pfam00702
    Location:289533
    Hydrolase; haloacid dehalogenase-like hydrolase
  2. NM_001310459.1NP_001297388.1  eyes absent homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001297388.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC119875, AC156988
    Consensus CDS
    CCDS78545.1
    UniProtKB/Swiss-Prot
    P97767
    Related
    ENSMUSP00000027066.7, ENSMUST00000027066.13
    Conserved Domains (1) summary
    cd02601
    Location:320591
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  3. NM_010164.2NP_034294.2  eyes absent homolog 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses two alternate in-frame splice junctions compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    BC060260
    Consensus CDS
    CCDS78546.1
    UniProtKB/TrEMBL
    F6YST4, Q6PAJ8
    Related
    ENSMUSP00000126383.4, ENSMUST00000168081.9
    Conserved Domains (3) summary
    TIGR01658
    Location:316587
    EYA-cons_domain; eyes absent protein conserved domain
    pfam00702
    Location:318562
    Hydrolase; haloacid dehalogenase-like hydrolase
    pfam03153
    Location:74250
    TFIIA; Transcription factor IIA, alpha/beta subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    14239177..14381259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495452.4XP_006495515.1  eyes absent homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_006495515.1

    Conserved Domains (1) summary
    cd02601
    Location:288533
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  2. XM_017315414.2XP_017170903.1  eyes absent homolog 1 isoform X8

    Conserved Domains (1) summary
    cd02601
    Location:204475
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  3. XM_006495451.4XP_006495514.1  eyes absent homolog 1 isoform X4

    Conserved Domains (2) summary
    cd02601
    Location:315586
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
    pfam03157
    Location:83308
    Glutenin_hmw; High molecular weight glutenin subunit
  4. XM_011238344.3XP_011236646.1  eyes absent homolog 1 isoform X2

    Conserved Domains (1) summary
    cd02601
    Location:321592
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  5. XM_011238346.3XP_011236648.1  eyes absent homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011236648.1

    Conserved Domains (1) summary
    cd02601
    Location:288533
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  6. XM_017315381.2XP_017170870.1  eyes absent homolog 1 isoform X5

    Conserved Domains (1) summary
    cd02601
    Location:288533
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  7. XM_006495446.5XP_006495509.1  eyes absent homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006495509.1

    Conserved Domains (1) summary
    cd02601
    Location:321566
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  8. XM_030247470.2XP_030103330.1  eyes absent homolog 1 isoform X1

    Conserved Domains (1) summary
    cd02601
    Location:321566
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  9. XM_017315348.3XP_017170837.1  eyes absent homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    P97767
    Related
    ENSMUSP00000141112.2, ENSMUST00000190337.7
    Conserved Domains (1) summary
    cd02601
    Location:320591
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  10. XM_017315422.3XP_017170911.1  eyes absent homolog 1 isoform X8

    Conserved Domains (1) summary
    cd02601
    Location:204475
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  11. XM_036159662.1XP_036015555.1  eyes absent homolog 1 isoform X7

    Conserved Domains (1) summary
    cd02601
    Location:199444
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
  12. XM_036159644.1XP_036015537.1  eyes absent homolog 1 isoform X6

    Conserved Domains (1) summary
    cl21460
    Location:321493
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  13. XM_036159667.1XP_036015560.1  eyes absent homolog 1 isoform X9

    Conserved Domains (1) summary
    cl21460
    Location:321381
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  14. XM_036159675.1XP_036015568.1  eyes absent homolog 1 isoform X10

RNA

  1. XR_001780756.2 RNA Sequence

Support Center