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Dmbx1 diencephalon/mesencephalon homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 140477, updated on 12-May-2024

Summary

Official Symbol
Dmbx1provided by MGI
Official Full Name
diencephalon/mesencephalon homeobox 1provided by MGI
Primary source
MGI:MGI:2153518
See related
Ensembl:ENSMUSG00000028707 AllianceGenome:MGI:2153518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atx; Mbx; Cdmx; Otx3
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult feeding behavior; adult locomotory behavior; and brain development. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb bud; and sensory organ. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 2.2), whole brain E14.5 (RPKM 1.7) and 4 other tissues See more
Orthologs
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Genomic context

See Dmbx1 in Genome Data Viewer
Location:
4 D1; 4 53.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115772316..115797794, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115915119..115940597, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene kinocilin Neighboring gene transmembrane protein 275 Neighboring gene STARR-seq mESC enhancer starr_11128 Neighboring gene predicted gene, 38492 Neighboring gene STARR-seq mESC enhancer starr_11131 Neighboring gene fatty acid amide hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
diencephalon/mesencephalon homeobox protein 1
Names
diencephalon/mesencephalon-expressed brain homeobox gene 1 protein
homeobox gene Atx
orthodenticle homolog 3
paired-like homeobox protein DMBX1
paired-type homeobox Atx

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025567.1NP_001020738.1  diencephalon/mesencephalon homeobox protein 1 isoform b

    See identical proteins and their annotated locations for NP_001020738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    BC050912, BY732319
    Consensus CDS
    CCDS18500.1
    UniProtKB/Swiss-Prot
    Q91ZK4
    Related
    ENSMUSP00000120320.3, ENSMUST00000124071.9
    Conserved Domains (1) summary
    pfam00046
    Location:69123
    Homeobox; Homeobox domain
  2. NM_130865.3NP_570935.3  diencephalon/mesencephalon homeobox protein 1 isoform a

    See identical proteins and their annotated locations for NP_570935.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC050912, BY732319, CN455087
    UniProtKB/Swiss-Prot
    B1ASG1, Q8CH43, Q8K4U6, Q8VHG8, Q91ZK3, Q91ZK4
    Conserved Domains (1) summary
    pfam00046
    Location:74128
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115772316..115797794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319958.2XP_017175447.1  diencephalon/mesencephalon homeobox protein 1 isoform X3

    UniProtKB/Swiss-Prot
    B1ASG1, Q8CH43, Q8K4U6, Q8VHG8, Q91ZK3, Q91ZK4
    Conserved Domains (1) summary
    pfam00046
    Location:74128
    Homeobox; Homeobox domain
  2. XM_030253193.1XP_030109053.1  diencephalon/mesencephalon homeobox protein 1 isoform X4

    Conserved Domains (1) summary
    pfam00046
    Location:69123
    Homeobox; Homeobox domain
  3. XM_017319959.2XP_017175448.1  diencephalon/mesencephalon homeobox protein 1 isoform X3

    UniProtKB/Swiss-Prot
    B1ASG1, Q8CH43, Q8K4U6, Q8VHG8, Q91ZK3, Q91ZK4
    Conserved Domains (1) summary
    pfam00046
    Location:74128
    Homeobox; Homeobox domain
  4. XM_017319957.2XP_017175446.1  diencephalon/mesencephalon homeobox protein 1 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:82136
    Homeobox; Homeobox domain
  5. XM_011240436.3XP_011238738.1  diencephalon/mesencephalon homeobox protein 1 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:77131
    Homeobox; Homeobox domain