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Muc4 mucin 4 [ Mus musculus (house mouse) ]

Gene ID: 140474, updated on 7-Apr-2019

Summary

Official Symbol
Muc4provided by MGI
Official Full Name
mucin 4provided by MGI
Primary source
MGI:MGI:2153525
See related
Ensembl:ENSMUSG00000079620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asgp; 4933405I11Rik
Summary
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface. A large 5' exon encodes at least 15 tandem repeats of 124-126 amino acids. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon adult (RPKM 15.2), large intestine adult (RPKM 5.6) and 6 other tissues See more
Orthologs

Genomic context

See Muc4 in Genome Data Viewer
Location:
16; 16 B3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (32735886..32782391)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (32735972..32782477)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 34825 Neighboring gene predicted gene, 41446 Neighboring gene mucin 20 Neighboring gene somatomedin B domain containing 1 Neighboring gene RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein Neighboring gene forty-two-three domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ErbB-2 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix constituent, lubricant activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mucin-4
Names
ascites sialoglycoprotein
mucin 4, ASGP
pancreatic adenocarcinoma mucin
testis mucin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080457.3NP_536705.3  mucin-4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC139244, AC161755
    UniProtKB/TrEMBL
    E9Q7Q0
    Related
    ENSMUSP00000093813.3, ENSMUST00000096106.9
    Conserved Domains (4) summary
    smart00723
    Location:26142726
    AMOP; Adhesion-associated domain present in MUC4 and other proteins
    smart00216
    Location:27302910
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:24582615
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    cd00054
    Location:33853421
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    32735886..32782391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183101.1: Suppressed sequence

    Description
    NM_183101.1: This RefSeq was permanently suppressed because it has a frameshift resulting in premature termination and a nonsense-mediated mRNA decay (NMD) candidate.
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