Muc4 mucin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc4provided by MGI
Official Full Name: mucin 4provided by MGI
Primary source: MGI:MGI:2153525
See related: Ensembl:ENSMUSG00000118672 AllianceGenome:MGI:2153525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asgp; 4933405I11Rik
Summary: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface. A large 5' exon encodes at least 15 tandem repeats of 124-126 amino acids. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon adult (RPKM 15.2), large intestine adult (RPKM 5.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 23.3 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (32555089..32602786)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (32735886..32782391)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model.
Title: Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model.
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis.
Title: Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis.
Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.
Title: Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.
Observations suggest that Muc4 may facilitate metastasis by promoting the association of circulating tumor cells with blood cells to augment tumor cell survival in circulation.
Title: Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer.
the role of Muc4 in driving intestinal inflammation and inflammation-associated tumorigenesis
Title: Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Title: Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer.
Using the Pdx1-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesions induced by mutated hK-ras is correlated with the ERK, JNK and NF-kappaB signaling pathways.
Title: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.
Data show that Muc4 is upregulated and interacts with erbB2 in gallbladders from BK5.erbB2 mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 signaling.
Title: Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 and its clinical significance for prognosis of pancreatic cancer.
Title: MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
Title: Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Not Applicable (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Muc4 (e-PCR), detects polymorphism
- UniSTS:239203

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ErbB-2 class receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ErbB-2 class receptor binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-4

Names: ascites sialoglycoprotein; mucin 4, ASGP; pancreatic adenocarcinoma mucin; testis mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080457.5 → NP_536705.4 mucin-4 precursor

Status: VALIDATED

Source sequence(s)

AC161755, MG954261

UniProtKB/Swiss-Prot

Q4VAA3, Q8JZM8, Q9ERB8, Q9QXG0, Q9WV36

UniProtKB/TrEMBL

A0A7N9VSW1

Related

ENSMUSP00000159443.2, ENSMUST00000239554.1

Conserved Domains (8) summary

smart00723
Location:3134 → 3246

AMOP; Adhesion-associated domain present in MUC4 and other proteins

smart00216
Location:3250 → 3430

VWD; von Willebrand factor (vWF) type D domain

smart00539
Location:2978 → 3135

NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins

COG3889
Location:355 → 434

COG3889; Predicted periplasmic protein [Function unknown]

PRK08581
Location:527 → 743

PRK08581; amidase domain-containing protein

cd00054
Location:3905 → 3941

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam05109
Location:1299 → 1718

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

NF033849
Location:2486 → 2776

ser_rich_anae_1; serine-rich protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

32555089..32602786

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_183101.1: Suppressed sequence

Description

NM_183101.1: This RefSeq was permanently suppressed because it has a frameshift resulting in premature termination and a nonsense-mediated mRNA decay (NMD) candidate.