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ASB7 ankyrin repeat and SOCS box containing 7 [ Homo sapiens (human) ]

Gene ID: 140460, updated on 29-Mar-2020

Summary

Official Symbol
ASB7provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 7provided by HGNC
Primary source
HGNC:HGNC:17182
See related
Ensembl:ENSG00000183475 MIM:615052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 4.8), thyroid (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See ASB7 in Genome Data Viewer
Location:
15q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (100602550..100651701)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101142755..101191906)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723335 Neighboring gene PRKX pseudogene 1 Neighboring gene RNA, U6 small nuclear 181, pseudogene Neighboring gene lines homolog 1 Neighboring gene WD repeat domain 12 pseudogene Neighboring gene uncharacterized LOC105371024 Neighboring gene protein enabled homolog Neighboring gene PHD finger protein 5H pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22551, FLJ25192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 7
Names
ASB-7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024708.3NP_078984.2  ankyrin repeat and SOCS box protein 7 isoform 1

    See identical proteins and their annotated locations for NP_078984.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AK026204, BC063581, CD632230
    Consensus CDS
    CCDS10388.1
    UniProtKB/Swiss-Prot
    Q9H672
    UniProtKB/TrEMBL
    A0A024RCD9
    Related
    ENSP00000339819.4, ENST00000343276.4
    Conserved Domains (2) summary
    cd00204
    Location:41170
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:81114
    ANK; ANK repeat [structural motif]
  2. NM_198243.3NP_937886.1  ankyrin repeat and SOCS box protein 7 isoform 2

    See identical proteins and their annotated locations for NP_937886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' CDS and UTR, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA830153, AC090695, AK289860, CD632230
    Consensus CDS
    CCDS10387.1
    UniProtKB/Swiss-Prot
    Q9H672
    UniProtKB/TrEMBL
    A0A024RC94
    Related
    ENSP00000328327.7, ENST00000332783.11
    Conserved Domains (3) summary
    PHA02875
    Location:21241
    PHA02875; ankyrin repeat protein; Provisional
    cd03726
    Location:273317
    SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:81114
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    100602550..100651701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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