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ASB5 ankyrin repeat and SOCS box containing 5 [ Homo sapiens (human) ]

Gene ID: 140458, updated on 18-Aug-2020

Summary

Official Symbol
ASB5provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 5provided by HGNC
Primary source
HGNC:HGNC:17180
See related
Ensembl:ENSG00000164122 MIM:615050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASB-5
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 5.3), urinary bladder (RPKM 4.0) and 6 other tissues See more
Orthologs

Genomic context

See ASB5 in Genome Data Viewer
Location:
4q34.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (176213673..176277571, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177134824..177198722, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 17 Neighboring gene spermatogenesis associated 4 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423 Neighboring gene signal peptidase complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 5
Names
SOCS box protein ASB-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080874.4NP_543150.1  ankyrin repeat and SOCS box protein 5

    See identical proteins and their annotated locations for NP_543150.1

    Status: REVIEWED

    Source sequence(s)
    AC093605, BX647857
    Consensus CDS
    CCDS3827.1
    UniProtKB/Swiss-Prot
    Q8WWX0
    UniProtKB/TrEMBL
    Q5HYF3
    Related
    ENSP00000296525.3, ENST00000296525.7
    Conserved Domains (3) summary
    cd00204
    Location:71188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:288329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71100
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    176213673..176277571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262759.1XP_005262816.1  ankyrin repeat and SOCS box protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005262816.1

    UniProtKB/Swiss-Prot
    Q8WWX0
    UniProtKB/TrEMBL
    Q5HYF3
    Conserved Domains (3) summary
    cd00204
    Location:71188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:288329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71100
    ANK; ANK repeat [structural motif]
  2. XM_011531617.3XP_011529919.1  ankyrin repeat and SOCS box protein 5 isoform X3

    See identical proteins and their annotated locations for XP_011529919.1

    UniProtKB/Swiss-Prot
    Q8WWX0
    Related
    ENSP00000422877.1, ENST00000512254.1
    Conserved Domains (3) summary
    cd00204
    Location:18135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1847
    ANK; ANK repeat [structural motif]
    cl02533
    Location:235276
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. XM_011531616.2XP_011529918.1  ankyrin repeat and SOCS box protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011529918.1

    Related
    ENSP00000500617.1, ENST00000672074.1
    Conserved Domains (4) summary
    cd00204
    Location:26143
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:243284
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    pfam12796
    Location:29120
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:2655
    ANK; ANK repeat [structural motif]
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