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ASB11 ankyrin repeat and SOCS box containing 11 [ Homo sapiens (human) ]

Gene ID: 140456, updated on 7-Oct-2019

Summary

Official Symbol
ASB11provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 11provided by HGNC
Primary source
HGNC:HGNC:17186
See related
Ensembl:ENSG00000165192 MIM:300626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue See more
Orthologs

Genomic context

See ASB11 in Genome Data Viewer
Location:
Xp22.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (15281697..15315640, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15293800..15333788, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724092 Neighboring gene ankyrin repeat and SOCS box containing 9 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene PIR-FIGF readthrough Neighboring gene vascular endothelial growth factor D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119168, MGC119169, DKFZp779E2460

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 11
Names
ASB-11
ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ankyrin repeat domain-containing SOCS box protein ASB11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012627.1 RefSeqGene

    Range
    4966..38909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012428.2NP_001012428.1  ankyrin repeat and SOCS box protein 11 isoform b

    See identical proteins and their annotated locations for NP_001012428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC095351, AF425642, BX537853, BX537857
    Consensus CDS
    CCDS35209.1
    UniProtKB/Swiss-Prot
    Q8WXH4
    UniProtKB/TrEMBL
    Q7Z670
    Related
    ENSP00000343408.4, ENST00000344384.8
    Conserved Domains (5) summary
    cd00204
    Location:45162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:261302
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:146237
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4597
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:4574
    ANK; ANK repeat [structural motif]
  2. NM_001201583.2NP_001188512.1  ankyrin repeat and SOCS box protein 11 isoform c

    See identical proteins and their annotated locations for NP_001188512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform 1.
    Source sequence(s)
    AC095351, BX537857
    Consensus CDS
    CCDS56596.1
    UniProtKB/Swiss-Prot
    Q8WXH4
    Related
    ENSP00000369837.3, ENST00000380470.7
    Conserved Domains (4) summary
    cd00204
    Location:108230
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:265306
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:150241
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:148176
    ANK; ANK repeat [structural motif]
  3. NM_080873.3NP_543149.1  ankyrin repeat and SOCS box protein 11 isoform a

    See identical proteins and their annotated locations for NP_543149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC095351, AF425642, BX537857
    Consensus CDS
    CCDS14164.1
    UniProtKB/Swiss-Prot
    Q8WXH4
    Related
    ENSP00000417914.1, ENST00000480796.6
    Conserved Domains (5) summary
    cd00204
    Location:66183
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03728
    Location:282323
    SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:167258
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:6695
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    15281697..15315640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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