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TCP10L t-complex 10 like [ Homo sapiens (human) ]

Gene ID: 140290, updated on 10-Oct-2023

Summary

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Official Symbol
TCP10Lprovided by HGNC
Official Full Name
t-complex 10 likeprovided by HGNC
Primary source
HGNC:HGNC:11657
See related
Ensembl:ENSG00000242220 MIM:608365; AllianceGenome:HGNC:11657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRED77; C21orf77; TCP10A-1; TCP10A-2; LINC00846
Summary
Enables several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 24.4) See more
Orthologs
all
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Genomic context

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See TCP10L in Genome Data Viewer
Location:
21q22.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32573721..32585523, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30923998..30951524, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33946031..33957833, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33870192-33870360 Neighboring gene exosome component 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33891510-33891675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33905149-33905650 Neighboring gene CFAP298-TCP10L readthrough Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:33933639-33934430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33934431-33935222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33941277-33941820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33941821-33942362 Neighboring gene RNA, 5S ribosomal pseudogene 490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33956090-33956590 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33957672-33957871 Neighboring gene Sharpr-MPRA regulatory region 410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18365 Neighboring gene cilia and flagella associated protein 298 Neighboring gene olfactory receptor family 7 subfamily E member 23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma. Shen S, et al. BMB Rep, 2020 Aug. PMID 32438969, Free PMC Article
  2. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. Zuo J, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24565846
  3. Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers. Jo YS, et al. Pathol Oncol Res, 2020 Jan. PMID 29532408
  4. TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction. Shen S, et al. BMB Rep, 2016 Jun. PMID 26698869, Free PMC Article
  5. Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif. Zhong Z, et al. Mol Biol Rep, 2008 Jun. PMID 17377852

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma.
    Title: TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma.
  2. Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers.
    Title: Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers.
  3. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.
    Title: TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.
  4. Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo.
    Title: TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.
  5. The result revealed that TCP10L expressed specifically in the human liver and testis
    Title: Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity.
  6. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3.
    Title: TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.
  7. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells.
    Title: Human liver specific transcriptional factor TCP10L binds to MAD4.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough CFAP298-TCP10L

Readthrough gene: CFAP298-TCP10L, Included gene: CFAP298

Homology

Clone Names

  • FLJ10932, MGC34297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
T-complex protein 10A homolog 1
Names
T-complex protein 10A homolog 2
T-complex protein 10A-1
T-complex protein 10A-2
TCP10-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144659.7 → NP_653260.1  T-complex protein 10A homolog 1

    See identical proteins and their annotated locations for NP_653260.1

    Status: VALIDATED

    Source sequence(s)
    AF115967, AP000274, BC027970, BG721020, HY036551
    Consensus CDS
    CCDS13616.1
    UniProtKB/Swiss-Prot
    Q53EW0, Q8TDR4, Q96LN5
    UniProtKB/TrEMBL
    J3KTL9
    Related
    ENSP00000300258.3, ENST00000300258.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    32573721..32585523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    30923998..30951524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018277.1: Suppressed sequence

    Description
    NM_018277.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDR4.1 GenPept UniProtKB/Swiss-Prot:Q8TDR4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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