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Bcl11a B cell CLL/lymphoma 11A (zinc finger protein) [ Mus musculus (house mouse) ]

Gene ID: 14025, updated on 5-Jan-2023

Summary

Official Symbol
Bcl11aprovided by MGI
Official Full Name
B cell CLL/lymphoma 11A (zinc finger protein)provided by MGI
Primary source
MGI:MGI:106190
See related
Ensembl:ENSMUSG00000000861 AllianceGenome:MGI:106190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Evi9; Ctip1; Evi9a; Evi9b; Evi9c; BCL-11A; mKIAA1809; 2810047E18Rik; D930021L15Rik
Summary
Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Acts upstream of or within B cell differentiation; T cell differentiation; and negative regulation of gene expression. Located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BAF chromatin remodeling complex subunit BCL11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 11.6), CNS E18 (RPKM 11.0) and 13 other tissues See more
Orthologs
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Genomic context

See Bcl11a in Genome Data Viewer
Location:
11; 11 A3.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (24026498..24123558)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (24076564..24173558)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene poly(A) polymerase gamma Neighboring gene predicted gene 12061 Neighboring gene RIKEN cDNA A830031A19 gene Neighboring gene uncharacterized LOC118567902 Neighboring gene RIKEN cDNA 4930538E20 gene Neighboring gene predicted gene 12066 Neighboring gene predicted gene, 33440 Neighboring gene predicted gene, 33379

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in paraspeckles ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
B-cell lymphoma/leukemia 11A
Names
B-cell CLL/lymphoma 11A
COUP-TF interacting protein 1
EVI-9
ecotropic viral integration site 9 protein
myeloid leukemia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159289.1NP_001152761.1  B-cell lymphoma/leukemia 11A isoform 2

    See identical proteins and their annotated locations for NP_001152761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 4.
    Source sequence(s)
    AA008362, AK004395, AK045556, BB853515, BY735002
    Consensus CDS
    CCDS48758.1
    UniProtKB/Swiss-Prot
    Q9QYE3
    Related
    ENSMUSP00000105142.2, ENSMUST00000109516.8
  2. NM_001159290.1NP_001152762.1  B-cell lymphoma/leukemia 11A isoform 3

    See identical proteins and their annotated locations for NP_001152762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, one of which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 3) is shorter when it is compared to isoform 4.
    Source sequence(s)
    AK045556
    Consensus CDS
    CCDS48759.1
    UniProtKB/Swiss-Prot
    Q9QYE3
    Related
    ENSMUSP00000112948.2, ENSMUST00000118955.2
  3. NM_001242934.1NP_001229863.1  B-cell lymphoma/leukemia 11A isoform 4

    See identical proteins and their annotated locations for NP_001229863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform 4).
    Source sequence(s)
    AK045556, AK140949, AK164574, BB649527, BB662872, BF731393, BY735002, CB524780, CD355476
    Consensus CDS
    CCDS56764.1
    UniProtKB/Swiss-Prot
    Q9QYE3
    UniProtKB/TrEMBL
    A0A8C6HBI0, Q3TP99, Q3US10, Q5STS9
    Related
    ENSMUSP00000105140.2, ENSMUST00000109514.8
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  4. NM_016707.3NP_057916.1  B-cell lymphoma/leukemia 11A isoform 1

    See identical proteins and their annotated locations for NP_057916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 1) has a shorter C-terminus when it is compared to isoform 4.
    Source sequence(s)
    AF169037, AL672018, BB649527, BY735002
    Consensus CDS
    CCDS24483.1
    UniProtKB/Swiss-Prot
    Q9JLK9, Q9QYE3
    UniProtKB/TrEMBL
    A0A8C6HC58
    Related
    ENSMUSP00000000881.7, ENSMUST00000000881.13
    Conserved Domains (3) summary
    sd00017
    Location:379399
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:378399
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    24026498..24123558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156319.1XP_036012212.1  B-cell lymphoma/leukemia 11A isoform X6

    UniProtKB/Swiss-Prot
    Q9JLK9
    UniProtKB/TrEMBL
    A0A8C6HC58
    Conserved Domains (3) summary
    sd00017
    Location:379399
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:378399
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  2. XM_036156320.1XP_036012213.1  B-cell lymphoma/leukemia 11A isoform X9

  3. XM_036156315.1XP_036012208.1  B-cell lymphoma/leukemia 11A isoform X1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  4. XM_036156318.1XP_036012211.1  B-cell lymphoma/leukemia 11A isoform X1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  5. XM_036156314.1XP_036012207.1  B-cell lymphoma/leukemia 11A isoform X1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011243659.3XP_011241961.1  B-cell lymphoma/leukemia 11A isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:379399
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  7. XM_036156321.1XP_036012214.1  B-cell lymphoma/leukemia 11A isoform X9

  8. XM_036156316.1XP_036012209.1  B-cell lymphoma/leukemia 11A isoform X1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006514504.4XP_006514567.1  B-cell lymphoma/leukemia 11A isoform X1

    See identical proteins and their annotated locations for XP_006514567.1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  10. XM_030245548.2XP_030101408.1  B-cell lymphoma/leukemia 11A isoform X9

  11. XM_036156322.1XP_036012215.1  B-cell lymphoma/leukemia 11A isoform X9

  12. XM_030245543.2XP_030101403.1  B-cell lymphoma/leukemia 11A isoform X4

    Conserved Domains (4) summary
    sd00017
    Location:345365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:709730
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  13. XM_011243660.3XP_011241962.1  B-cell lymphoma/leukemia 11A isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:709730
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  14. XM_036156317.1XP_036012210.1  B-cell lymphoma/leukemia 11A isoform X1

    UniProtKB/TrEMBL
    A0A8C6HBI0, Q5STS9
    Conserved Domains (3) summary
    sd00017
    Location:744764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:743764
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain
  15. XM_030245545.1XP_030101405.1  B-cell lymphoma/leukemia 11A isoform X7

    Conserved Domains (3) summary
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:657678
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:305330
    zf-H2C2_2; Zinc-finger double domain
  16. XM_030245547.2XP_030101407.1  B-cell lymphoma/leukemia 11A isoform X8

    Conserved Domains (3) summary
    sd00019
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:326347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339364
    zf-H2C2_2; Zinc-finger double domain
  17. XM_006514507.4XP_006514570.1  B-cell lymphoma/leukemia 11A isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:692712
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:691712
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339364
    zf-H2C2_2; Zinc-finger double domain