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Etv6 ets variant 6 [ Mus musculus (house mouse) ]

Gene ID: 14011, updated on 14-May-2024

Summary

Official Symbol
Etv6provided by MGI
Official Full Name
ets variant 6provided by MGI
Primary source
MGI:MGI:109336
See related
Ensembl:ENSMUSG00000030199 AllianceGenome:MGI:109336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tel
Summary
This gene encodes a transcriptional repressor belonging to the ETS family of proteins. Knockout of this gene in mice results in embryonic lethality due to defective angiogenesis. In humans, this gene is often involved in chromosome rearrangements associated with specific cancers. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in ovary adult (RPKM 13.6), bladder adult (RPKM 11.2) and 28 other tissues See more
Orthologs
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Genomic context

See Etv6 in Genome Data Viewer
Location:
6 G1; 6 64.58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134012663..134247121)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134035700..134270158)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:133826058-133826359 Neighboring gene kidney androgen regulated protein Neighboring gene STARR-positive B cell enhancer ABC_E8142 Neighboring gene STARR-seq mESC enhancer starr_17533 Neighboring gene STARR-seq mESC enhancer starr_17535 Neighboring gene predicted gene 8956 Neighboring gene STARR-positive B cell enhancer ABC_E3686 Neighboring gene STARR-positive B cell enhancer ABC_E8143 Neighboring gene STARR-positive B cell enhancer ABC_E4873 Neighboring gene predicted gene, 46978 Neighboring gene predicted gene, 52920 Neighboring gene STARR-positive B cell enhancer ABC_E3687 Neighboring gene STARR-positive B cell enhancer ABC_E9281 Neighboring gene RIKEN cDNA 1700051K13 gene Neighboring gene STARR-seq mESC enhancer starr_17540 Neighboring gene predicted gene, 38908 Neighboring gene predicted gene 17089 Neighboring gene RIKEN cDNA 4933406J09 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134288078-134288378 Neighboring gene STARR-seq mESC enhancer starr_17542 Neighboring gene STARR-positive B cell enhancer ABC_E10413 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134339435-134339735 Neighboring gene STARR-seq mESC enhancer starr_17545 Neighboring gene BCL2 like 14 Neighboring gene low density lipoprotein receptor-related protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transcription factor ETV6
Names
ETS-related protein Tel1
ets variant gene 6 (TEL oncogene)
translocation-ets-leukemia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303102.1NP_001290031.1  transcription factor ETV6 isoform 2

    See identical proteins and their annotated locations for NP_001290031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068908, AC113600, AC145116
    UniProtKB/TrEMBL
    Q3U037, Q80WR3
    Related
    ENSMUSP00000107594.2, ENSMUST00000111963.8
    Conserved Domains (3) summary
    cd08535
    Location:1481
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:291377
    ETS; erythroblast transformation specific domain
    pfam09770
    Location:89227
    PAT1; Topoisomerase II-associated protein PAT1
  2. NM_007961.4NP_031987.3  transcription factor ETV6 isoform 1

    See identical proteins and their annotated locations for NP_031987.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068908, AC113600, AC145116
    Consensus CDS
    CCDS39677.1
    UniProtKB/Swiss-Prot
    P97360
    UniProtKB/TrEMBL
    Q8CBV1
    Related
    ENSMUSP00000079818.7, ENSMUST00000081028.13
    Conserved Domains (2) summary
    cd08535
    Location:57124
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:334420
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    134012663..134247121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241206.4XP_011239508.1  transcription factor ETV6 isoform X1

    See identical proteins and their annotated locations for XP_011239508.1

    UniProtKB/TrEMBL
    Q3U037, Q80WR3
    Conserved Domains (3) summary
    cd08535
    Location:1481
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:291377
    ETS; erythroblast transformation specific domain
    pfam09770
    Location:89227
    PAT1; Topoisomerase II-associated protein PAT1
  2. XM_011241207.4XP_011239509.1  transcription factor ETV6 isoform X1

    See identical proteins and their annotated locations for XP_011239509.1

    UniProtKB/TrEMBL
    Q3U037, Q80WR3
    Conserved Domains (3) summary
    cd08535
    Location:1481
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:291377
    ETS; erythroblast transformation specific domain
    pfam09770
    Location:89227
    PAT1; Topoisomerase II-associated protein PAT1
  3. XM_011241208.4XP_011239510.1  transcription factor ETV6 isoform X1

    See identical proteins and their annotated locations for XP_011239510.1

    UniProtKB/TrEMBL
    Q3U037, Q80WR3
    Conserved Domains (3) summary
    cd08535
    Location:1481
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:291377
    ETS; erythroblast transformation specific domain
    pfam09770
    Location:89227
    PAT1; Topoisomerase II-associated protein PAT1