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Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 14004, updated on 12-May-2024

Summary

Official Symbol
Chchd2provided by MGI
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 2provided by MGI
Primary source
MGI:MGI:1261428
See related
Ensembl:ENSMUSG00000070493 AllianceGenome:MGI:1261428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etohi6
Summary
Predicted to enable DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to oxidative stress; positive regulation of mitochondrial ATP synthesis coupled electron transport; and regulation of cellular response to hypoxia. Located in mitochondrion. Is expressed in several structures, including diaphragm; gonad; head mesenchyme; heart ventricle; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Parkinson's disease 22. Orthologous to human CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 1404.4), duodenum adult (RPKM 1158.2) and 28 other tissues See more
Orthologs
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Genomic context

See Chchd2 in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129910002..129916311, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129881161..129887470, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5 Neighboring gene nuclear protein transcriptional regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103085

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 2
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial
ethanol induced 6
NP_077128.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024166.6NP_077128.2  coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_077128.2

    Status: PROVISIONAL

    Source sequence(s)
    AC164071, AC242408
    Consensus CDS
    CCDS19702.1
    UniProtKB/Swiss-Prot
    Q3TUG8, Q9D1L0
    Related
    ENSMUSP00000091835.4, ENSMUST00000094280.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129910002..129916311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)